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Merck

A5486

Azoximetano

13.4 M, ≥98%

Sinónimos:

AOM

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Fórmula lineal:
CH3N=N(→O)CH3
Número CAS:
Peso molecular:
74.08
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352124
MDL number:
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Nombre del producto

Azoximetano, 13.4 M, ≥98%

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

assay

≥98%

form

liquid

composition

methylene chloride, ≤1%

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

13.4 M

color

colorless

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

application(s)

genomic analysis

storage temp.

−20°C

Quality Level

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Application

El azoximetano (AOM), un mutágeno génico, puede utilizarse con el sulfato de dextrano de sodio (DSS) para crear modelos de cáncer en animales de laboratorio que pueden utilizarse para estudiar los mecanismos de progresión y quimioprevención del cáncer.

Biochem/physiol Actions

Carcinógeno que induce aductos de O6-metilguanina en el ADN que dan lugar a transiciones G→A. Induce tumorogénesis en el colon de los animales de laboratorio y se utiliza para estudiar el mecanismo de la progresión y la quimioprevención del cáncer.

Features and Benefits

Versátil y adaptable para una amplia variedad de aplicaciones de laboratorio y experimentales

General description

El azoximetano (AOM) es un potente químico de laboratorio utilizado para estudiar el inicio, la progresión y la prevención del cáncer, particularmente de colon. Actúa como cancerígeno, desencadenando la formación de tumores, y como agente de mutación genética, causando alteraciones específicas en el ADN.

Other Notes

Es fundamental determinar la dosis correcta de azoximetano para el diseño experimental con el fin de evitar la muerte prematura de los animales de laboratorio.
Si desea más información sobre nuestra gama de productos bioquímicos, cumplimente este formulario.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C


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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What solvents can be used to dissolve Azoxymethane?

    Azoxymethane is soluble in water, ether, ethanol, and chloroform. The reported solubility in chlorform is 200 mg/mL, and in water is 100 mg/mL.

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

  8. How does azoxymethane act to cause cancers?

    Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

  9. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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