A9041
Arg-Gly-Asp-Ser
≥95% (HPLC)
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Fórmula empírica (notación de Hill):
C15H27N7O8
Número CAS:
Peso molecular:
433.42
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
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Permítanos ayudarleNombre del producto
Arg-Gly-Asp-Ser, ≥95% (HPLC)
Quality Level
InChI
1S/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)/t7-,8-,9-/m0/s1
SMILES string
N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
InChI key
NNRFRJQMBSBXGO-CIUDSAMLSA-N
biological source
synthetic
assay
≥95% (HPLC)
form
powder
composition
Peptide content, ~70%
technique(s)
cell culture | mammalian: suitable
storage temp.
−20°C
Gene Information
human ... ITGA2B(3674), ITGB3(3690)
mouse ... Itgb3(16416)
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Application
Arg-Gly-Asp-Ser has been used:
- to study its effects on cell attachment in rats
- to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
- to pretreat the cells, to assess the role of integrin in the cell attachment process
- to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)
General description
The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.
RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ß1 (TGFß1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages
RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ß1 (TGFß1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages
Other Notes
Lyophilized from 0.1% TFA in H2O
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
This product is soluble in water (1 mg/ml), yielding a
clear, colorless solution.
clear, colorless solution.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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