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Merck

C3865

Anti-N-Cadherin antibody, Mouse monoclonal

clone GC-4, purified from hybridoma cell culture

Sinónimos:

Anti-A-CAM, Anti-A-Cell Adhesion Molecule

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UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00164511
Conjugate:
unconjugated
Clone:
GC-4, monoclonal
Application:
electron microscopy
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Species reactivity:
chicken, monkey, mouse, human, rabbit, rat
Citations:
68
Technique(s):
electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
Uniprot accession no.:
P19022

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Nombre del producto

Anti-N-Cadherin antibody, Mouse monoclonal, clone GC-4, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

GC-4, monoclonal

form

buffered aqueous solution

mol wt

antigen 135 kDa

species reactivity

chicken, monkey, mouse, human, rabbit, rat

technique(s)

electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts

isotype

IgG1

UniProt accession no.

P19022

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)

Categorías relacionadas

Application

Anti-N-Cadherin antibody is suitable for the following procedures:
  • electron microscopy
  • flow cytometry
  • immunocytochemistry
  • immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
  • western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts

Biochem/physiol Actions

CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.

Other Notes

Clone GC-4 is also known as GB-9.

Physical form

0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
069M4864V
22190131
058M4845V
22171219
087M4751V

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Priscilla Y Hwang et al.
Cellular and molecular bioengineering, 8(1), 51-62 (2015-04-08)
Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with strong cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with aging-associated changes in
Emilie Duchalais et al.
Cellular and molecular gastroenterology and hepatology, 5(1), 31-49 (2017-12-01)
In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells.
Gang Chen et al.
Nature communications, 7, 12531-12531 (2016-08-20)
Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duration of pain. Intrathecal injection of the mu-opioid
Telomerase and N-Cadherin Differential Importance in Adrenocortical Cancers and Adenomas.
Pereira SS, et al.
Journal of Cellular Biochemistry, 118(8), 2064-2071 (2017)
Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.
Nelson ER, et al.
Oncotarget, 7(51), 84030-84030 (2016)
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