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Merck

C8273

Cytochalasin D

From Zygosporium mansonii, ≥98% (TLC and HPLC), actin polymerization inhibitor, powder

Sinónimos:

Lygosporin A, Zygosporin A

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Fórmula empírica (notación de Hill):
C30H37NO6
Número CAS:
22144-77-0
Peso molecular:
507.62
NACRES:
NA.77
PubChem Substance ID:
24893039
UNSPSC Code:
12352200
EC Number:
244-804-1
MDL number:
MFCD00077706
Beilstein/REAXYS Number:
1632828

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Nombre del producto

Cytochalasin D, from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

InChI key

SDZRWUKZFQQKKV-JHADDHBZSA-N

SMILES string

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

biological source

Zygosporium mansonii

assay

≥98% (TLC and HPLC)

form

powder

solubility

DMSO: soluble
ethanol: soluble

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

−20°C

Quality Level

300

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Application

Cytochalasin D has been used:
  • to treat H9c2 cells to study the relationship between cell stiffness and the F-actin cytoskeleton
  • as inhibitor of receptor-mediated endocytosis to treat oligodendrocyte precursor cells (OPCs) to investigate the effect of inhibiting specific extracellular vesicle (EV) uptake pathways
  • in in vitro embryo culture to artificially activate oocytes

Biochem/physiol Actions

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

General description

Cytochalasin D is a cell-permeable fungal toxin. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Cytochalasin D inhibits smooth muscle contraction and insulin-stimulated but not basal transport of glucose.
Cytochalasin D (CytoD) is commonly used to inhibit actin dynamics and study its role in cellular processes. This fungal-derived small organic compound acts as an inhibitor of the interaction between G-actin and cofilin by binding to G-actin. Additionally, CytoD inhibits the binding of cofilin to F-actin and reduces the rate of actin polymerization and depolymerization in living cells.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
069M4071V
14181017
128M4013V
068M4013V
058M4035V

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