E4013
Monoclonal Anti-Elastin antibody produced in mouse
clone BA-4, ascites fluid
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Conjugate:
unconjugated
Clone:
BA-4, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
microarray
microarray
Species reactivity:
human, goat, sheep, guinea pig, pig, canine, feline, bovine
Citations:
33
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using sheep arterial tissue
microarray: suitable
microarray: suitable
Uniprot accession no.:
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Permítanos ayudarleNombre del producto
Monoclonal Anti-Elastin antibody produced in mouse, clone BA-4, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
BA-4, monoclonal
mol wt
antigen 67.5 kDa
contains
15 mM sodium azide
species reactivity
human, goat, sheep, guinea pig, pig, canine, feline, bovine
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using sheep arterial tissue
microarray: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ELN(2006)
Categorías relacionadas
Application
Monoclonal Anti-Elastin antibody produced in mouse has been used in:
- immunohistochemistry
- immunostaining
- immunoblotting
Biochem/physiol Actions
Elastin is encoded by the ELN gene in humans. It is a polymeric protein in connective tissue that has exceptional properties of extension, elastic recoil to the extracellular matrix and allows many tissues in the body to resume their shape after stretching or contracting. Elastin is a self-assembling, extracellular-matrix protein providing tissue elasticity and is predominantly comprised of cross-linked tropoelastin. It plays an important role in the atherosclerotic process. The conformational disorder is caused due to a constitutive feature of elastin structure and function.
Elastin undergoes changes of morphology with aging and in many disease states. For example, abnormal accumulation of connective tissue in blood vessels contributes to alterations in vascular physiology associated with diseases such as hypertension and atherosclerosis. Several heritable diseases such as Marfan syndrome, pseudoxanthoma elasticum and the Buschke-Ollendorf syndrome may result from molecular defects of elastin.
The antibody binds to insoluble elastin, α-elastin, tropoelastin (the soluble non-cross linked precursor of elastin) and to peptide fragments generated by proteolytic digestion of insoluble elastin. In tropoelastin preparations, three immunoreactive bands have been observed at 67.5 kDa, 65 kDa and 62 kDa corresponding to the three elastin isoforms. The antibody is specific for an epitope composed of the repeated sequence in elastin: Val-Gly-Val-Ala-Pro-Gly. This epitope has been shown to be a chemoattractant for fibroblasts and monocytes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Elastin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Elastin is an important polymeric protein of connective tissue. It is synthesized and secreted as a soluble single-chain protein (tropoelastin) that undergoes numerous post-ribosomal modifications prior to the organization of the elastic fiber in the extracellular space.
Immunogen
bovine α-elastin.
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Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yeo GC, et al.
Advanced Helathcare Materials, 4(16), 2530-2530 (2015)
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The Journal of clinical and aesthetic dermatology, 3(12), 22-30 (2011-01-05)
Electro-optical synergy technology is one of the most recently described methods for nonablative skin rejuvenation. The aim of this study is to evaluate the effects of electro-optical synergy on connective tissue composition by histological and immunohistochemical techniques coupled with computerized
Moetaz El-Domyati et al.
International journal of dermatology, 51(8), 913-919 (2012-07-14)
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Moetaz El-Domyati et al.
Journal of cosmetic dermatology, 11(2), 122-130 (2012-06-08)
As the demand for minimally invasive rejuvenation is increasing, micropeel resurfacing using Erbium:Yttrium Aluminum Garnet (Er:YAG) laser 2940 nm has been reported for the treatment of photoaged skin without ablation of the epidermis. However, little is known about the efficacy
Kinon Chen et al.
Annals of biomedical engineering, 42(3), 678-684 (2013-11-16)
Age-related macular degeneration (AMD) etiology is unknown, but its association to atherosclerotic vascular disease (ASVD) has been observed. Since elastin plays an important role in the atherosclerotic process, to understand ASVD and AMD's relationship we examined retinal elastin existence, elastin
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