F8807
FM19G11
≥98% (HPLC)
Sinónimos:
3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester, [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C23H17N3O8
Número CAS:
Peso molecular:
463.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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Permítanos ayudarleInChI
1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
SMILES string
Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
InChI key
XVUOIWIIQVGWAJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white to light brown
solubility
DMSO: ≥40 mg/mL
storage temp.
2-8°C
Quality Level
Categorías relacionadas
Application
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factor α (HIFα), reported to affect self-renewal and differentiation of stem cells.
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Chao-Guo You et al.
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FM19G11 is a small molecular agent that inhibits hypoxia-inducible factor-1-alpha (HIF-1α) and other signaling pathways. In this study, we characterized the modulating effects of FM19G11 on O6 -methylguanine DNA-methyltransferase (MGMT), the main regulator of temozolomide (TMZ) resistance in glioblastomas. This
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Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4
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American journal of physiology. Gastrointestinal and liver physiology, 307(7), G673-G688 (2014-06-28)
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