G2879
Glycine hydrochloride
≥99% (HPLC), NMDA receptors regulator, powder
Sinónimos:
Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
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Fórmula lineal:
H2NCH2CO2H · HCl
Número CAS:
Peso molecular:
111.53
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.32
EC Number:
227-841-8
MDL number:
Servicio técnico
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Permítanos ayudarleNombre del producto
Glycine hydrochloride, ≥99% (HPLC)
Quality Level
assay
≥99% (HPLC)
form
powder
mol wt
111.53
storage condition
(Tightly closed Dry)
concentration
≤100%
technique(s)
immunohistochemistry: suitable
mp
176-180 °C (lit.)
solubility
water: 0.5 g/mL, clear, colorless
storage temp.
room temp
SMILES string
Cl.NCC(O)=O
InChI
1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
InChI key
IVLXQGJVBGMLRR-UHFFFAOYSA-N
General description
Research area: Neuroscience
Application
Glycine hydrochloride has been used:
- in the preparation of glycine-HCl buffer
- to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
- to regenerate the sensor to elute the bound C-reactive protein (CRP)
Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Biochem/physiol Actions
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.
Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1
Clase de almacenamiento
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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