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Merck

G5422

β-Glycerophosphate disodium salt hydrate

≤1.0 mol % L-α-isomer

Sinónimos:

BGP, Glycerol 2-phosphate disodium salt hydrate

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Fórmula lineal:
(HOCH2)2CHOP(O)(ONa)2 · xH2O
Número CAS:
154804-51-0
Peso molecular:
216.04 (anhydrous basis)
NACRES:
NA.25
PubChem Substance ID:
329799941
UNSPSC Code:
12352201
EC Number:
212-464-3
MDL number:
MFCD00149082

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Nombre del producto

β-Glycerophosphate disodium salt hydrate, ≤1.0 mol % L-α-isomer

InChI

1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2

InChI key

ROPZSVKNEIIIDE-UHFFFAOYSA-L

SMILES string

O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

biological source

synthetic

form

powder

impurities

≤0.1% Inorganic phosphorus
≤1.0 mol % L-α-isomer

mp

102-104 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

Quality Level

300

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Analysis Note

Low inorganic phosphate content. Mixtures of α- and β-glycerophosphate have historically been used in microbiological media but high levels of inorganic (free) phosphate has been associated with the irregular growth of bacteria and unwanted precipitates.

Application

β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.
β-glycerophosphate is used in homegenization solutions for muscles extracts following fixation.
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
SLBN5612V
SLCH0942
SLCD3944
SLCC7836
SLCB7369

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Morten Donsmark et al.
The Journal of physiology, 550(Pt 3), 845-854 (2003-06-10)
Intramuscular triacylglycerol is an important energy store and is also related to insulin resistance. The mobilization of fatty acids from this pool is probably regulated by hormone-sensitive lipase (HSL), which has recently been shown to exist in muscle and to
J Douglas et al.
The Journal of applied bacteriology, 56(2), 321-326 (1984-04-01)
An easily prepared medium, originally designed for the cultivation of lactic phages, has been found to have much wider application. Experience in its use over a ten year period with a range of physiologically diverse bacteria, for teaching and research
Yang An et al.
Biochemical and biophysical research communications, 516(2), 551-557 (2019-06-27)
Developing methods for regenerating bones and uncovering the molecular mechanism underlying bone formation have great significance to human health. In the last decade, people have been using adipose-derived stem cells (ADSCs), that are capable of multilineage differentiation, to reconstruct defected
Guoqiang Zhao et al.
Marine pollution bulletin, 149, 110582-110582 (2019-09-25)
Phosphorus (P) pollution can trigger severe marine eutrophication, which further leads to harmful algal blooms, and a deterioration of sea water quality. The P burial and regeneration in offshore sediments can directly affect the eutrophication levels of estuarine and coastal
Lucas R Brun et al.
SpringerPlus, 3, 676-676 (2014-12-19)
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of SrR in bisphosphonate-naïve patients (BP-naïve) compared to patients previously
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