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H0135

Hydrocortisone

Name: Hydrocortisone
Brand: SIGMA

γ-irradiated, powder, BioXtra, suitable for cell culture

Sinónimos:

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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Fórmula empírica (notación de Hill):

C₂₁H₃₀O₅

Número CAS:

50-23-7

Peso molecular:

362.46

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24895394

EC Number:

200-020-1

Beilstein/REAXYS Number:

1354819

MDL number:

MFCD00011654

Biological source:

synthetic (organic)

Form:

powder

Assay:

≥80% (HPLC)

Servicio técnico

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Propiedades

biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

assay

≥80% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

211-214 °C (lit.)

solubility

ethanol: 1 mg/mL, clear

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

Descripción

General description

Hydrocortisone for use in epithelial and endothelial adherent cell culture applications.

Application

Hydrocortisone is used for the following applications:

Used in myogenic induction and identification
Used in long-term stromal cultures and methylcellulose cultures (one of the components in the culture medium)
Used in adipogenic differentiation (one of the components in adipogenic medium)
Used in cell culture: The human mammary epithelial cell MCF-10A cells were maintained in DMEM/F12 and supplemented with hydrocortisone along with other components
The SUM149 cell line was established from a primary IBC and grown in FBS supplemented with Ham′s F12 medium containing insulin and hydrocortisone
Used in differentiation assays of melanoma spheroid cells

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Primary glucocorticoid secreted by the adrenal cortex.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 50 μg/mL stock solution; add 1 mL absolute ethanol, gently swirl to dissolve, add 19 mL sterile medium while mixing.

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pictograms

GHS08

signalword

Danger

hcodes

H360Df,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1A - STOT RE 2

target_organs

Adrenal gland,Bone marrow

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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