L0664
Loxoprofen
solid
Sinónimos:
α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid, Koloxo
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C15H18O3
Número CAS:
Peso molecular:
246.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
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Permítanos ayudarleInChI
1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)
SMILES string
CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1
InChI key
YMBXTVYHTMGZDW-UHFFFAOYSA-N
form
solid
originator
Daiichi-Sankyo
Quality Level
Gene Information
human ... PTGS1(5742), PTGS2(5743)
Application
Anti-inflammatory; analgesic
Features and Benefits
This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Tetsuya Katsumori et al.
Cardiovascular and interventional radiology, 40(11), 1687-1693 (2017-05-17)
To compare acute pain after uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM) versus gelatin sponge particles (GS) for leiomyoma. This was a single-institution, retrospective study. Between July 2008 and November 2016, 101 consecutive patients with symptomatic uterine leiomyoma
Shintaro Suemasu et al.
Biochemical pharmacology, 84(11), 1470-1481 (2012-10-02)
We previously proposed that direct cytotoxicity of NSAIDs due to their membrane permeabilization activity, together with their ability to decrease gastric prostaglandin E(2), contributes to production of gastric lesions. Compared to loxoprofen (LOX), fluoro-loxoprofen (F-LOX) has much lower membrane permeabilization
S Kawai
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 47 Suppl 2, S102-S106 (1998-11-27)
Severe gastro-intestinal complications are a major cause of NSAID-induced deaths in cases of rheumatoid arthritis. We measured COX selectivity by using an intact cell assay system, and found that NS-398 is a highly COX-2-selective inhibitor. Meloxicam, etodolac and diclofenac also
Naoki Yamakawa et al.
Bioorganic & medicinal chemistry, 19(11), 3299-3311 (2011-05-17)
Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX-2, are responsible for the majority of COX activity at the gastrointestinal mucosa and in tissues with inflammation, respectively. We
Youngbae Kim et al.
Archives of pharmacal research, 41(4), 459-466 (2018-03-25)
Loxoprofen is a non-steroidal anti-inflammatory drug of the 2-arylpropionic acid type, which has used to treat musculoskeletal disorders in the horse racing industry. However, it has also used illicitly to mask clinical signs of inflammation and pain in racehorses. Thus
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