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Merck

LO4200

LOPAC®1280 - pequeña escala

International Version

Sinónimos:

Library of Pharmacologically Active Compounds - small scale

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UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Form:
liquid
Quality level:
100

Documentos clave

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Nombre del producto

LOPAC®1280 - pequeña escala, International Version

form

liquid

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

shipped in

dry ice

storage temp.

−20°C

Quality Level

100

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Application

Library of pharmacologically active compounds LOPAC®1280 - small scale has been used to screen for the suppressors of niclosamide- and nigericin-induced interleukin (IL-1β) release.

Features and Benefits

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position

General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).

Other Notes

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO4100.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

188.6 °F

flash_point_c

87 °C

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Certificados de análisis (COA)

Lot/Batch Number
057M4730V
086M4755V
066M4735V
085M4605V
124M4608V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the difference between the LOPAC1280 Products LO4100 and LO4200?

    These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.

  6. Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    There is no CAS number list available.

  7. Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?

    Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at techserv@sial.com or 1800-325-5832.

  8. What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?

    The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.

  9. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?

    Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.

  10. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200  US approved?

    About 30% of the collection is made up of drugs approved for use in the US.

  11. Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    The information is available in the datasheet of a similar product LO1280.

  12. What is the difference between the LOPAC1280 Products LO4200 and LO1280?

    The compound per well in LO4200 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280.

  13. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be useful in enabling compound prioritization based on their spectrum
Kurumi Y Horiuchi et al.
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James Robinson et al.
Assay and drug development technologies, 11(8), 468-477 (2013-10-15)
The galanin 3 receptor (GalR3) belongs to the large G protein-coupled receptor (GPCR) family of proteins. GalR3 and two other closely related receptors, GalR1 and GalR2, together with their endogenous ligand galanin, are involved in a variety of physiological and
John S Lazo et al.
Molecular pharmacology, 72(1), 1-7 (2007-04-05)
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of
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