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Merck

M0763

Metoclopramide hydrochloride

D2 antagonist, solid

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Fórmula empírica (notación de Hill):
C14H22ClN3O2 · HCl
Número CAS:
7232-21-5
Peso molecular:
336.26
NACRES:
NA.77
PubChem Substance ID:
24277919
UNSPSC Code:
12352200
EC Number:
230-634-5
MDL number:
MFCD00058011

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Nombre del producto

Metoclopramide hydrochloride, solid

InChI

1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H

InChI key

RVFUNJWWXKCWNS-UHFFFAOYSA-N

SMILES string

Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

form

solid

color

white

solubility

H2O: soluble

originator

Baxter

Quality Level

100

Gene Information

human ... DRD2(1813), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360)

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Biochem/physiol Actions

D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCQ4308
MKCL8990
MKCB8741
MKBW1899V
MKBS3618V

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R W Pero et al.
Molecular and cellular biochemistry, 193(1-2), 119-125 (1999-05-20)
Our laboratory has concentrated on the possible regulation the benzamides and nicotinamides may have on the processes of DNA repair and apoptosis. Recent reports have suggested that both apoptosis and inflammation are regulated by the transcription factor NF-kappaB. We have
B Y De Winter et al.
Gut, 45(5), 713-718 (1999-10-13)
The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These effects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT(3)) receptor antagonist, and a
M K Ladola et al.
Indian journal of pharmaceutical sciences, 76(5), 423-429 (2014-11-27)
In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone and Kyron T-314 were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. The
Diogo F Antunes et al.
Molecular and cellular endocrinology, 550, 111649-111649 (2022-04-19)
Dopamine is part of the reward system triggering the social decision-making network in the brain. It has hence great potential importance in the regulation of social behaviour, but its significance in the control of behaviour in highly social animals is
Mark L Kovler et al.
Science translational medicine, 13(612), eabg3459-eabg3459 (2021-09-23)
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, whose pathogenesis remains incompletely understood, although activation of the Gram-negative bacterial receptor Toll-like receptor 4 (TLR4) on the intestinal epithelium plays a critical role. Patients with NEC typically display gastrointestinal
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