P0040
PP1
≥98% (HPLC), PTK inhibitor, powder
Sinónimos:
4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C16H19N5
Número CAS:
Peso molecular:
281.36
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Permítanos ayudarleNombre del producto
PP1, ≥98% (HPLC)
SMILES string
Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
InChI key
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
InChI
1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
Quality Level
Application
PP1 has been used as:
- an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
- a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
- a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)
Biochem/physiol Actions
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.
PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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