P8139
Forbol 12-miristato 13-acetato
≥99% (TLC), film or powder, PKC activator
Sinónimos:
12-O-Tetradecanoilforbol 13-acetato, 4β,9α,12β,13α,20-Pentahidroxitiglia-1,6-dien-3-ona 12-tetradecanoato 13-acetato, PMA, TPA
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Nombre del producto
Forbol 12-miristato 13-acetato, ≥99% (TLC), film or powder
InChI
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
SMILES string
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
InChI key
PHEDXBVPIONUQT-RGYGYFBISA-N
assay
≥99% (TLC)
form
film or powder
solubility
DMSO: soluble
ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)
storage temp.
−20°C
Quality Level
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Application
- para inducir la diferenciación de los monocitos THP-1 a macrófagos.
- para estimular la proliferación de linfocitos de sangre periférica.
- para inducir estallidos respiratorios y mejorar la generación de emisión de fotones ultra débiles (UPE) de las células neutrofiloides derivadas de las células HL-60.
- en conjugación con la sal de calcio de la ionomicina para estimular la activación de las células T
- para la estimulación de varias células, como las del bazo, los linfocitos quiescentes y los timocitos fetales.
- para la activación de la PKC (proteína cinasa C) en las células.
Disclaimer
Features and Benefits
General description
signalword
Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
Clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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What is the difference between Phorbol 12-myristate 13-acetate, Product P8139 and molecular biology grade Product P1585?
Product P1585 has been tested and found suitable for stimulation of interleukin 2 production of Jurkat cells. Product P8139 has not tested in this application.
Why do I not see any solid in the Phorbol 12-myristate 13-acetate bottle, Product P8139?
Phorbol 12-myristate 13-acetate may be an invisible film in the bottle.
How should Product P8139, Phorbol 12-myristate 13-acetatebe dissolved?
Stock solutions of 20 mM can be prepared in DMSO and diluted into aqueous buffers. View more information on P8139 solubility in the product information sheet (under Documents, above).
How should I store the solutions of Product P8139, Phorbol 12-myristate 13-acetate?
Stock solutions in DMSO can be stored protected from light as aliquots at -20°C for at least 6 months, or at 2-8°C for up to 3 months.
Do you have any application information for Product P8139, Phorbol 12-myristate 13-acetate?
View the P8139 product information sheet (under Documents, above).
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
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