PZ0012
Sunitinib malate
≥98% (HPLC), powder, receptor tyrosine kinase inhibitor
Sinónimos:
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248
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Nombre del producto
Sunitinib malate, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL
storage temp.
room temp
SMILES string
O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI
1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
InChI key
LBWFXVZLPYTWQI-IPOVEDGCSA-N
Gene Information
human ... CSF1R(1436), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), KIT(3815), PDGFRA(5156), PDGFRB(5159), RET(5979)
Application
- to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis
- as a reference molecule to compare its docking energies with other ligands/vascular endothelial growth factor receptor (VEGF) receptor blocker
- used in proliferation assay
Biochem/physiol Actions
Features and Benefits
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B - STOT RE 1 Oral
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
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