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Merck

RAB0802

Mouse IgG1 ELISA Kit

Sinónimos:

IgG1, Immunoglobulin G1

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Acerca de este artículo

NACRES:
NA.32
UNSPSC Code:
41116158
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species reactivity

mouse

technique(s)

ELISA: suitable

assay range

inter-assay cv: <10%
intra-assay cv: <12%

shipped in

wet ice

storage temp.

−20°C

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

General description

Immunoglobulin G (IgG) is the most prevalent protein found in the human serum. About 10–20% of plasma protein accounts for IgG. IgG1 is the major Ig isotype in murine serum. It resembles human IgG4 functionally. Murine immunoglobulin G1 (IgG1) is capable of blocking the complex formation of IgG2a, IgG2b, and IgG3 with C1q. C1q-mediated complement activation by IgG2a can be blocked by murine IgG1. Because of their likely inhibitory influence on both complement and classical Fcγ receptor (FcγR) activation, murine IgG1 may have the greatest inhibitory capacity toward all other IgG types. The antibody pair provided in this kit recognizes mouse IgG1.

pictograms

Corrosion

signalword

Warning

hcodes

Hazard Classifications

Met. Corr. 1

Clase de almacenamiento

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable


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Frontiers in immunology, 9, 958-958 (2018-06-06)
IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs. This interaction is dependent on
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Although morbidity and mortality rates from asthma are highest in patients > 65 years of age, the effect of older age on airway inflammation in asthma is not well established. To investigate age-related differences in the promotion of allergic inflammation

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