Saltar al contenido
Merck

S193

Anti-Synapsin I antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Acerca de este artículo

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00282157
Conjugate:
unconjugated
Clone:
polyclonal
Application:
dot blot
immunohistochemistry (frozen sections)
immunoprecipitation (IP)
indirect immunofluorescence
western blot
Species reactivity:
rat, mouse, human, bovine
Citations:
41
Technique(s):
dot blot: 1:1000
immunohistochemistry (frozen sections): 1:2000
immunoprecipitation (IP): 1 μg
indirect immunofluorescence: 1:2000
western blot: 1:1000
Uniprot accession no.:
P17600

Documentos clave

Ver Toda la documentación
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle

Nombre del producto

Anti-Synapsin I antibody produced in rabbit, affinity isolated antibody, lyophilized powder

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen ~80 kDa (Synapsin Ia)

species reactivity

rat, mouse, human, bovine

technique(s)

dot blot: 1:1000
immunohistochemistry (frozen sections): 1:2000
immunoprecipitation (IP): 1 μg
indirect immunofluorescence: 1:2000
western blot: 1:1000

UniProt accession no.

P17600

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SYN1(6853)
mouse ... Syn1(20964)
rat ... Syn1(24949)

Immunogen

synapsin I from bovine brain.

Physical form

Lyophilized from ammonium bicarbonate (5 mM)

Biochem/physiol Actions

Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.


Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.

General description

Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Clase de almacenamiento

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCR1511
MKCQ3004
MKCP6001
MKCN0670
MKCL6148

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356? mutation in synapsin I.
Giannandrea M, et al.
PLoS ONE, 8(6), e67724-e67724 (2013)
Synapsin III: role in neuronal plasticity and disease.
Porton B, et al.
Seminars in Cell & Developmental Biology, 22(4), 416-424 (2011)
Increased synapsin I expression in cerebral malaria.
Thonsranoi K, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 13996-13996 (2015)
P De Camilli et al.
The Journal of cell biology, 96(5), 1337-1354 (1983-05-01)
Synapsin I (formerly referred to as protein I) is the collective name for two almost identical phosphoproteins, synapsin Ia and synapsin Ib (protein Ia and protein Ib), present in the nervous system. Synapsin I has previously been shown by immunoperoxidase
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.
Huttner W B, et al.
The Journal of Cell Biology, 96(5), 1374-1388 (1983)
Ver todos los artículos relacionados

Contenido relacionado

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico