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Merck

S5069

Anti-Superoxide Dismutase (MnSOD) (DD-17) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-IPO-B, Anti-Indophenoloxidase B, Anti-MNSOD, Anti-Manganese Dependent SOD, Anti-Manganese Superoxide Dismutase 2, Anti-Mitochodrial SOD, Anti-Mn-SOD, Anti-SOD2, Anti-Superoxide Dismutase 2

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UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD06798545
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
indirect immunofluorescence
western blot
western blot
Species reactivity:
rat, human
Citations:
16
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using biotin/ExtraAvidin®-peroxidase staining of human heart sections
indirect immunofluorescence: 10-20 μg/mL using methanol-acetone-fixed rat NRK cells
western blot: 1-2 μg/mL using human HeLa mitochondria extract and a chemiluminescent detection reagent
western blot: 2-4 μg/mL using whole extract of rat brain and a chemiluminescent detection reagent
Uniprot accession no.:
P04179

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Nombre del producto

Anti-Superoxide Dismutase (MnSOD) (DD-17) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~24 kDa

species reactivity

rat, human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using biotin/ExtraAvidin®-peroxidase staining of human heart sections
indirect immunofluorescence: 10-20 μg/mL using methanol-acetone-fixed rat NRK cells
western blot: 1-2 μg/mL using human HeLa mitochondria extract and a chemiluminescent detection reagent
western blot: 2-4 μg/mL using whole extract of rat brain and a chemiluminescent detection reagent

UniProt accession no.

P04179

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... SOD2(6648)
rat ... Sod2(24787)

Categorías relacionadas

Application

The antibody may be detected by various immunochemical techniques including immunoblotting, co-immunoprecipitation assay (co-IP), immunoprecipitation, indirect immunofluorescence and immunohistochemistry.

Biochem/physiol Actions

Superoxide Dismutase (SOD) catalyzes the dismutation of the cytotoxic superoxide radical (O2 -) to molecular oxygen and hydrogen peroxide. Manganese SOD (MnSOD) has been proposed to function as a tumor suppressor by modulating the activity of redox-sensitive transcription factors and specific signal mediators. MnSOD is involved in detoxification.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Superoxide Dismutase (SOD) is a metalloprotein enzyme. It is widely distributed in the animal and plant kingdoms. The three common mammalian endogenous isozymes are the homodimeric copper-zinc SOD (Cu,ZnSOD, SOD1) found primarily in the cytosol, the homotetrameric glycosylated copper-zinc SOD, extracellular SOD (EC-SOD, SOD3), and the homotetrameric mitochondrial manganese SOD (MnSOD, SOD2). All three are nuclear-encoded. MnSOD is composed of four subunits, each containing one Mn2+.

Immunogen

synthetic peptide corresponding to amino acid residues 183-199 of human superoxide dismutase (MnSOD) with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is conserved in many eukaryotes.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Legal Information

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

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Clase de almacenamiento

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
055M4782V
093M4780
032M4828
080M4813
108K4784

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Visite la Librería de documentos

Melanie F Brown et al.
Mechanisms of ageing and development, 128(11-12), 696-705 (2007-11-30)
Eukaryotic cells have evolved elaborate mechanisms to preserve the fidelity of their genomic material in the face of chronic attack by reactive byproducts of aerobic metabolism. These mechanisms include antioxidant and DNA repair enzymes. Skin fibroblasts of long-lived mammalian species
SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma
Chang B, et al.
Scientific reports, 6 (2016)
Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt
Lai Y, et al.
International Journal of Molecular Medicine, 37(2), 369-377 (2016)
Tetramerization reinforces the dimer interface of MnSOD
Sheng Y, et al.
PLoS ONE, 8(5), e62446-e62446 (2013)
SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma
Chang B, et al.
Scientific Reports, 6 (2016)
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