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Merck

SAB1305554

Anti-β-Actin (ACTB) Antibody

mouse monoclonal, 137CT26.1.1

Sinónimos:

ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin

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UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
137CT26.1.1, monoclonal
Species reactivity:
mouse, human
Application:
immunofluorescence
immunohistochemistry
western blot
Technique(s):
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000
Citations:
5
Uniprot accession no.:
P60709

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Nombre del producto

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse, clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution

biological source

mouse

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

137CT26.1.1, monoclonal

form

buffered aqueous solution

mol wt

41737 Da

species reactivity

mouse, human

technique(s)

immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000

isotype

IgG1κ

NCBI accession no.

NP_001092.1

UniProt accession no.

P60709

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ACTB(60)

Application

Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.

Biochem/physiol Actions

β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

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Clase de almacenamiento

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SG100806AD

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Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold
Mizutami T, et al.
Advances in Biochemical Engineering null
Zunshu Du et al.
Aging cell, 20(8), e13437-e13437 (2021-07-23)
Synapse degeneration correlates strongly with cognitive impairments in Alzheimer's disease (AD) patients. Soluble Amyloid-beta (Aβ) oligomers are thought as the major trigger of synaptic malfunctions. Our earlier studies have demonstrated that Aβ oligomers interfere with synaptic function through N-methyl-D-aspartate receptors
Qifeng Deng et al.
Redox biology, 49, 102217-102217 (2021-12-24)
Maintaining host iron homeostasis is an essential component of nutritional immunity responsible for sequestrating iron from pathogens and controlling infection. Nucleotide-oligomerization domain-like receptors (NLRs) contribute to cytoplasmic sensing and antimicrobial response orchestration. However, it remains unknown whether and how NLRs

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