SAB4501984
Anti-NRF2 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
HEBP1, NF-E2 related factor 2, NF2L2, NFE2-related factor 2, NFE2L2
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Acerca de este artículo
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
18
Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 67 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NFE2L2(4780)
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General description
Anti-NRF2 Antibody detects endogenous levels of total NRF2 protein.
NRF2 (nuclear factor, erythroid 2 like 2) gene is mapped to human chromosome 2q31.2. The encoded protein is localized to dendritic cells. It belongs to the cap ′n′ collar (CNC) family of transcription factors.
Immunogen
The antiserum was produced against synthesized peptide derived from human Nrf2.
Immunogen Range: 556-605
Immunogen Range: 556-605
Application
Anti-NRF2, C-Terminal antibody produced in rabbit has been used in western blotting analysis.
Biochem/physiol Actions
Nrf2 (nuclear factor, erythroid 2 like 2) is involved in the regulation of anti-oxidative and anti-inflammatory response. The protein encoded is a transcription factor that binds to the antioxidant response element of the target gene. In response to oxidative stress, Nrf2 upregulates the enzymes associated with detoxification, anti-inflammation, cytoprotection and antioxidative pathways. Nrf2 affects glucose metabolism and ROS (reactive oxygen species) homeostasis in cancer cells by regulating the pentose phosphate pathway. Thus, Nrf2 is known to contribute to the development of cancer by promoting cell proliferation.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Xin Liu et al.
Biochimica et biophysica acta, 1863(8), 2093-2103 (2016-05-18)
The cap 'n' collar (CNC) family of transcription factors play important roles in resistance of oxidative and electrophilic stresses. Among the CNC family members, NF-E2-related factor 2 (Nrf2) is critical for regulating the antioxidant and phase II enzymes through antioxidant
Jianjian Wu et al.
Phytotherapy research : PTR, 37(1), 310-328 (2022-09-11)
Prostate cancer (PCa) is the most common malignant tumor in males, which frequently develops into castration-resistant prostate cancer (CRPC) with limited therapies. Gambogenic acid (GNA), a flavonoids compound isolated from Gamboge, exhibits anti-tumor capacity in various cancers. Our results showed
Martin Adam et al.
International journal of cardiology, 228, 341-346 (2016-11-21)
Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a
Daihong Cao et al.
Molecular medicine reports, 25(6) (2022-04-28)
It has been reported that oxidative stress plays a prominent role in diabetic macrovascular diseases. 3,4‑Dihydroxyacetophenone (3,4‑DHAP) has been found to have a variety of biological activities. However, few studies have assessed the antioxidant capacity of 3,4‑DHAP and the underlying
Lingli Hu et al.
Experimental and therapeutic medicine, 20(1), 283-292 (2020-06-20)
Glucocorticoids (GCs) exert a therapeutic effect in numerous chronic inflammatory diseases. However, chronic obstructive pulmonary disease (COPD) tends to be GC-resistant. Icariin, a major component of flavonoids isolated from Epimedium brevicornum Maxim (Berberidaceae), significantly relieves symptoms in patients with COPD.
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