Saltar al contenido
Merck

SBR00123

Colistin Sulfate

Ready Made Solution, 10 mg/mL (in H2O)

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Acerca de este artículo

UNSPSC Code:
51101500

Documentos clave

Ver Toda la documentación
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle

Nombre del producto

Colistin Sulfate, Ready Made Solution, 10 mg/mL (in H2O)

InChI

1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1

InChI key

ZJIWRHLZXQPFAD-LRYSGCCDSA-N

SMILES string

CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O

form

ready-to-use solution

concentration

10 mg/mL (in H2O)

color

colorless to yellow

antibiotic activity spectrum

Gram-negative bacteria

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

2-8°C

Quality Level

200

Biochem/physiol Actions

Mode of Action: Colistin mode of action is by forming electrostatic interaction with lipid A phosphate groups of lipopolysaccharide (LPS) of gram negative bacilli1 and disrupting physical integrity of the cell wall.2 Colistin shows indirect anti-endotoxin activity by binding to lipid A as it targets the endotoxin and neutralize the LPS component of the bacteria.[3-5]

Antimicrobial Spectrum: Colistin has microbial activity against Enterobacteriaceae family members like E. coli, Enterobacter spp., Klebsiella spp., Citrobacter spp., Salmonella spp., and Shigella spp. Colistin is also active against nonfermentive gram-negative bacteria, like Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia [6-8] and also against other gram negative species.[9]

Features and Benefits

High quality antibiotic suitable for mulitple research applications

General description

Colistin (Polymyxin E) is a polycationic peptide antimicrobial agent that inhibits gram negative bacteria.

Application

  • Colistin has been used for multi drug resistant infections bacilli like: Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii.[9-13]
  • To permeabilize to bacteria cell membrane to learn mannose-resistant haemagglutination and antibiotic resistance in A. baumannii  strain.[14]
  • For nephrotoxicity study in rat kidney.[15] and for MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa.[16]
  • To induce cell toxicity in 24h on PC-12 cell line, causing decrease of cell viability ~by 75% with concentration of 125µg/ml colistin sulfate.[17]
  • To show cell toxicity affect in dose (3-100µg/ml) dependent manner against HK-2 cells as part of a study to learn on the mechanism of colistin inducing nephrotoxicity.[18]

Preparation Note

Colistin Ready Made Solution is provided as a solution of 10mg/ml in water and aseptically dispensed.Colistin concentration range for the uses or applications mentioned above is 0.25-125µg/ml.Colistin Ready Made Solution should be diluted respectively by 80-40,000.

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.

Si necesita más asistencia, póngase en contacto con Atención al cliente

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico