Name: MISSION® siRNA Product Offerings
Brand: SIGMA

Product Resources Title

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<h2>Predesigned siRNA</h2>
Extensive collection of human, mouse and rat siRNA. Multiple sequences are available for every gene, with rankings to indicate performance.
<ul>
<li>Scale: 10, 25, 50, and 250 nmol</li>
<li>Purification: Desalt or HPLC</li>
<li>Sequence Length: 21 bases</li>
<li>Modifications: Not available for this item</li>
<li>Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.</li>
<li>Format: Supplied dry</li>
</ul>

Positive Control siRNA.
<ul>
<li>Validated human and rat positive controls to simplify transfection optimization.</li>
</ul>

<h2>siRNA Controls</h2>
Universal Negative Controls
<ul>
<li>Two distinct siRNA control sequences designed for use in Human, Mouse, or Rat cells.</li>
<li>Validated with Agilent 40K human gene arrays to ensure no significant nonspecific gene interactions.</li>
<li>Functionally validated to show no immune response via qRT PCR.</li>
</ul>

<h2>MISSION® siRNA Transfection Reagent</h2>
<ul>
<li>Superior gene silencing in a wide variety of eukaryotic cell types</li>
<li>For use with siRNA, esiRNA, miRNA mimics and Synthetic miRNA inhibitors</li>
</ul>

<h2>Fast siRNA</h2>
Expedite your siRNA order! Orders are prioritized in the production process with a turn-around-time of only 3 days.
<ul>
<li>FAST siRNA is delivered in solution at concentrations of 50 µM (2 OD) or 100 µM (5 OD).</li>
<li>US orders must be received by 11 AM CST. European orders must be received by 11 AM CET.</li>
<li>Easy to use Fast siRNA ordering tool.</li>
</ul>

<h2>Custom siRNA</h2>
Custom siRNA sequences with a wide range of modifications, purifications and quantities to tailor your unique sequence.
<ul>
<li>Scale: 10, 25, 50, and 250 nmol</li>
<li>Purification: Desalt or HPLC</li>
<li>Sequence Lengths: 19 - 27 bases</li>
<li>Modifications: Comprehensive offering of modifications and dyes (2'-O-Methyl, Amine, Cyanine dyes, 6-FAM, Biotin, Phosphate, Thiol, Abasic, Phosphorothioate linkages, 2'-Fluoro).</li>
<li>Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.</li>
<li>For additional purifications, sequence length or modifications, 
email <a href="mailto:sirnarequest@sial.com">sirnarequest@sial.com</a></li>
<li>Custom siRNA sequence design available for a variety of species, 
<a href="/services/support/sirna-design-service" target="_self">Learn more</a></li>
</ul>

<h2>iScale Oligos™ - siRNA</h2>
siRNA provided in larger quantities for in vivo, high throughput or diagnostic projects.
<ul>
<li>Amount: 1 – 10 mg, 50 mg – 1 g</li>
<li>Purification: Desalt, RPC (cartridge purified), HPLC and In vivo quality</li>
<li>Sequence Length: 19 - 45 bases</li>
<li>Comprehensive offering of modifications including dyes, amines, biotin, linkers, etc.</li>
<li>Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.</li>
<li>In vivo option includes HPLC-purification to &gt;/= 90%, desalt, filtration and endotoxin testing.</li>
<li>To inquire for availability of additional quantities, modifications or purifications, email <a href="mailto:sirnarequest@sial.com">sirnarequest@sial.com</a></li>
</ul>

<h2>RNA Oligos</h2>
<ul>
<li>Scale: 0.05, 0.2, 1.0 µmol</li>
<li>Purification: Desalt, HPLC and PAGE</li>
<li>Sequence Length: 7 - 45 bases</li>
<li>Modification options available</li>
<li>Quality Control: 100% Mass Spectrometry</li>
<li>Format: Supplied dry</li>
<li>Learn more about <a href="/technical-documents/technical-article/genomics/pcr/custom-rna-oligos" target="_self">RNA Oligos</a></li>
</ul>

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MISSION® siRNA Product Offerings Custom and Predesigned siRNA; Synonyms: Custom siRNA,High-throughput siRNA,Predesigned siRNA,siRNA,siRNA pools at Sigma-Aldrich

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MISSION^® siRNA Product Offerings

Custom and Predesigned siRNA

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