SML0282
Bexarotene
≥98% (HPLC), retinoid X receptor (RXR) agonist, powder
Sinónimos:
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid, LGD-1069, SR-11247
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Fórmula empírica (notación de Hill):
C24H28O2
Número CAS:
Peso molecular:
348.48
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Permítanos ayudarleNombre del producto
Bexarotene, ≥98% (HPLC)
SMILES string
C=C(C1=CC=C(C(O)=O)C=C1)C2=C(C)C=C3C(C(C)(C)CCC3(C)C)=C2
InChI
1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChI key
NAVMQTYZDKMPEU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥15 mg/mL (warmed)
storage temp.
−20°C
Quality Level
Gene Information
human ... RXRA(6256), RXRB(6257), RXRG(6258)
Categorías relacionadas
Application
Bexarotene has been used as retinoid x receptor (RXR) agonist:
- to study its effect on human oral squamous cell carcinoma (OSCC) cell lines
- to test for cooperative cell killing of cutaneous T cell lymphoma (CTCL) with 966
- as a standard in HPLC for determining its potential impurities in drug substances and drug products
Bexarotene has been used:
- to investigate its effects on the changes in renal, cardiac, hepatic, and pulmonary expression/activity of inducible nitric oxide synthase (iNOS) and CYP4F6
- to analyze the involvement of retinoid x receptor (RXR) homo or permissive heterodimers
- to study its potential impurities in drug substances and drug products
Biochem/physiol Actions
Bexarotene is a highly selective retinoid X receptor (RXR) agonist and an antineoplastic agent.
Bexarotene is a highly selective retinoid X receptor (RXR) agonist. It is an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer′s model lowered the most toxic form of β-amyloid peptide and increased cognitive ability. The activity in the mouse Alzheimer′s models are believed to be by activating PPARγ:RXR and LXR:RXR dimers which induces the expression of apoE and facilitates Aβ clearance and promotes microglial phagocytosis.
Bexarotene is used to treat breast cancer.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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