SML0618
NSC697923
≥98% (HPLC)
Sinónimos:
2-Nitro-5-tosylfuran, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-Furan
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Acerca de este artículo
Fórmula empírica (notación de Hill):
C11H9NO5S
Número CAS:
Peso molecular:
267.26
UNSPSC Code:
12352200
NACRES:
NA.77
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleServicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleNombre del producto
NSC697923, ≥98% (HPLC)
SMILES string
[S](=O)(=O)(c2[o]c(cc2)[N+](=O)[O-])c1ccc(cc1)C
InChI
1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
InChI key
GAUHIPWCDXOLCZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
NSC697923 has been used as an inhibitor in STING-dependent NF-κB (nuclear factor-κB) activation after DNA damage, mediated by TRAF6 (TNF receptor-associated factor 6).
Biochem/physiol Actions
NSC697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A that blocks the formation of the Ubc13 - ubiquitin thioester conjugate, and suppresses constitutive NF-kB activity in ABC-DLBCL cells. Also, NSC697923 inhibits the proliferation and survival of ABC-DLBCL and GCB-DLBCL cancer cells.
NSC697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A.
General description
NSC697923 stimulates apoptosis in p53 mutant neuroblastoma (NB) cells by triggering JNK (c-Jun N-terminal kinases) pathway. This ubiquitin-conjugating enzyme E2 N (UBE2N) inhibitor is considered as an important treatment option for neuroblastoma (NB) patients. NSC697923 prevents the multiplication and survival of diffuse large B-cell lymphoma (DLBCL) cells in vitro.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
Dunphy G, et al.
Molecular Cell, 71(5), 745-760 (2018)
J Cheng et al.
Cell death & disease, 5, e1079-e1079 (2014-02-22)
Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, is an E2 ubiquitin-conjugating enzyme that
Curtis D Hodge et al.
ACS chemical biology, 10(7), 1718-1728 (2015-04-25)
Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of Ubc13 with two inhibitors, NSC697923 and BAY 11-7082, which inhibit DNA damage and NF-κB
Kim Ghilarducci et al.
The FEBS journal, 288(16), 4849-4868 (2021-03-03)
Protein ubiquitination has been historically associated with protein degradation, but recent studies have demonstrated other cellular functions associated with substrate ubiquitination. Among the RING-type ubiquitin E3 ligase enzymes present in the human genome, RNF167 is a transmembrane protein located in
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico