U0881
Ácido úrico
BioXtra, ≥99% (HPLC)
Sinónimos:
2,6,8-Trihidroxipurina
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C5H4N4O3
Número CAS:
Peso molecular:
168.11
UNSPSC Code:
12352005
NACRES:
NA.55
PubChem Substance ID:
EC Number:
200-720-7
Beilstein/REAXYS Number:
156158
MDL number:
Assay:
≥99% (HPLC)
Biological source:
animal (seabird feces (guano))
Form:
powder
Solubility:
1 M NaOH: soluble 50 mg/mL, clear, faintly yellow
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Permítanos ayudarleInChI key
LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI
1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
SMILES string
O=C1NC(=O)C2=C(N1)NC(=O)N2
biological source
animal (seabird feces (guano))
product line
BioXtra
assay
≥99% (HPLC)
form
powder
impurities
≤0.005% Phosphorus (P)
ign. residue
≤0.1%
mp
>300 °C (lit.)
solubility
1 M NaOH: soluble 50 mg/mL, clear, faintly yellow
cation traces
Al: ≤0.005%, Ca: ≤0.01%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.05%, Mg: ≤0.001%, NH4+: ≤0.05%, Na: ≤0.1%, Pb: ≤0.001%, Zn: ≤0.0005%
Quality Level
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General description
Uric acid is the terminal product of purine degradation in humans. It is formed from the action of xanthine oxidase upon xanthine. Elevated levels of uric acid may clinically be manifested as gout. In species other than humans, uric acid can be further metabolized. In mammals other than primates, uric acid is converted to allantoin. In teleost fish, allantoin is further converted to allantoate, which is hydrolyzed to urea and glyoxylate. Uric acid may also be used in the biosynthesis of purines. It has been studied as a scavenger of biological free radicals like peroxynitrite. High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods for uric acid have been published. Uric acid promotes monocyte chemoattractant protein-1 (MCP-1) expression in vascular smooth muscle cells.
Application
Uric acid has been used:
- to prepare monosodium urate (MSU) crystals to study its effect on nuclear localization leucine-rich-repeat protein 1 (NLRP1) gene expression
- as a reductant to test its protective potential against met-myoglobin formation
- to prepare MSU to study its use as specific ligand of Clec12a.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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John Kanellis et al.
Hypertension (Dallas, Tex. : 1979), 41(6), 1287-1293 (2003-05-14)
Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC) proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory effects on VSMCs. Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte
Waleed Al Abdulmonem et al.
Protein and peptide letters, 28(3), 282-289 (2020-09-23)
Myoglobin is an oxygen binding protein and its dysfunction has been associated with the pathology of several human disorders. This study was undertaken to investigation the role of hydrogen peroxide (H2O2) in the formation of met-myoglobin and the protective potential
Francesca Viazzi et al.
Pediatrics, 132(1), e93-e99 (2013-06-19)
Hyperuricemia has been shown to be a strong correlate of hypertension in children. However, the complex interaction between serum uric acid (UA), systemic blood pressure (BP), and possibly confounding factors has been elucidated only in part. We evaluated office BP
S F Seys et al.
Allergy, 70(2), 187-194 (2014-11-02)
Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite
Tom M Palmer et al.
BMJ (Clinical research ed.), 347, f4262-f4262 (2013-07-23)
To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as
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