V7259
Vascular Endothelial Growth Factor human
≥98% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture
Sinónimos:
VEGF
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Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE)
Form:
powder
Mol wt:
protein 38.2 kDa (as homodimer)
Impurities:
≤0.1 EU/μg
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Permítanos ayudarleNombre del producto
Vascular Endothelial Growth Factor human, VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
powder
potency
1-10 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
protein 38.2 kDa (as homodimer)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤0.1 EU/μg
color
white
solubility
water: soluble
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... VEGFA(7422)
General description
Monomer consists of 165 amino acid residues, approx. mol. weight 19.2 kDa
Vascular Endothelial Growth Factor (VEGF) gene is localized to human chromosome 6p21.3, and is thought to encode four different isoforms.
Application
Vascular Endothelial Growth Factor (VEGF) has been used for-
- the determination of oligodendrocyte precursor cells (OPCs) and luteal cell proliferation/survival
- inducing proliferation of epithelial cell clusters (ECCs) to be transplanted into mice
Biochem/physiol Actions
Vascular Endothelial Growth Factor (VEGF), also known as vasculotropin, is an angiogenic growth factor, which is heat and acid stable. VEGFs stimulate endothelial cell growth, angiogenisis, and capillary permeability. VEGF is a secreted homodimeric, heparin-binding glycoprotein,1 which has an isoelectric point of 8.5. VEGF promotes the growth of endothelial cells isolated from bovine adrenal cortex, cerebral cortex, fetal and adult aorta, and human umbilical vein. The target cell specificity of VEGF is restricted to vascular endothelial cells. VEGF has no mitogenic effect on cultured corneal endothelial cells, vascular smooth muscle cells, BHK-12 fibroblasts, keratinocytes, human sarcoma cells, or lens epithelial cells. A variety of human tumor cell lines including sarcoma and carcinoma cells show a 3.7 kb RNA transcript that hybridizes with the VEGF probe in a Northern blot. Mouse sarcoma 180 cells express the VEGF mRNA and secrete a VEGF-like mitogen.
VEGF recombinant protein might have potential as a therapeutic agent in treatment-resistant disorders, where it can facilitate endothelial cell growth and vessel formation.
VEGF recombinant protein might have potential as a therapeutic agent in treatment-resistant disorders, where it can facilitate endothelial cell growth and vessel formation.
Physical form
Lyophilized from a sterile filtered buffered solution with no additives.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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