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Merck

1095506

USP

Carbidopa

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C10H14N2O4 · H2O
Número CAS:
Peso molecular:
244.24
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI

1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1

SMILES string

O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O

InChI key

QTAOMKOIBXZKND-PPHPATTJSA-N

grade

pharmaceutical primary standard

API family

carbidopa

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... DDC(1644)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Carbidopa USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Carbidopa and Levodopa Extended-Release Tablets
  • Carbidopa and Levodopa Orally Disintegrating Tablets
  • Carbidopa and Levodopa Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Mohseni Mehran S M et al.
Journal of clinical and diagnostic research : JCDR, 7(6), 1004-1007 (2013-08-02)
According to many studies, sprouted fava beans are a rich source of levo-dihydroxy phenylalanine (L-dopa) the precursor of dopamine, and they are now being investigated for use in the management of Parkinson's disease. The addition of Carbidopa (C-dopa) can reduce
Q. Alan Xu, Timothy L. Madden
Analytical Methods for Therapeutic Drug Monitoring and Toxicology, 80-80 (2011)
Ina Schabram et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(44), 14769-14776 (2014-10-31)
Methylphenidate (MPH) inhibits the reuptake of dopamine and noradrenaline. PET studies with MPH challenge show increased competition at postsynaptic D2/3-receptors, thus indirectly revealing presynaptic dopamine release. We used [(18)F]fluorodopamine ([(18)F]FDOPA)-PET in conjunction with the inlet-outlet model (IOM) of Kumakura et
J I Sage et al.
Clinical neuropharmacology, 17 Suppl 2, S1-S6 (1994-01-01)
This article reviews the pharmacokinetics of Sinemet CR, a controlled-release (CR) levodopa preparation. The main influences on the kinetic profile are as follows: absorption, which depends on the dissolution characteristics of the tablet, the pattern of gastric emptying, and the
Péter Klivényi et al.
Ideggyogyaszati szemle, 67(1-2), 5-8 (2014-03-25)
The motor complications in advanced Parkinson's disease may interfere with the quality of life. To overcome this disability, a jejunal levodopa pump was developed. In this review we have summarized the published clinical data with this method.

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