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Merck

1356632

USP

Ketoprofen

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

2-(3-Benzoylphenyl)propionic acid

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Fórmula empírica (notación de Hill):
C16H14O3
Número CAS:
22071-15-4
Peso molecular:
254.28
NACRES:
NA.24
PubChem Substance ID:
329750217
UNSPSC Code:
41116107
MDL number:
MFCD00055790

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InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

ketoprofen

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Ketoprofen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Ketoprofen Capsules
  • Ketoprofen Extended-Release Capsules

Biochem/physiol Actions

Non-steroidal anti-inflammatory compound that is selective for COX-1.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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H Bagheri et al.
Drug safety, 22(5), 339-349 (2000-06-01)
The topical use of nonsteroidal anti-inflammatory drugs (NSAIDs), widely used for moderate acute and chronic painful conditions, is one of several strategies used to improve the tolerability profile of NSAIDs, particularly with regard to gastric and renal adverse effects. However
M Sugiura et al.
Contact dermatitis, 43(1), 16-19 (2000-07-21)
We report 4 cases of photocontact dermatitis due to ketoprofen, a non-steroidal anti-inflammatory drug derived from propionic acid. We carried out a skin biopsy to examine the amount of ketoprofen in the eruptive skin. We investigated the cross-reactions between tiaprofenic
Igor E Shohin et al.
Journal of pharmaceutical sciences, 101(10), 3593-3603 (2012-07-13)
Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing ketoprofen are reviewed. Ketoprofen's solubility and permeability, its therapeutic use and
G Serrano et al.
Journal of the American Academy of Dermatology, 27(2 Pt 1), 204-208 (1992-08-01)
Photosensitivity reactions to fibric acid derivatives are not well understood and have been rarely reported. The aim of this study was to describe two cases of photosensitivity, one induced by fenofibrate and one by bezafibrate; to study the in vivo
Akihiko Ouchi et al.
Chirality, 14(1), 1-11 (2001-12-19)
The reactivity of organic molecules can be modified upon complexation with proteins: these changes can be different and more significant when the substrate is in an electronically excited state. Here we review UV, CD, and fluorescence spectroscopy studies on the
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