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Merck

1612517

USP

Sertraline hydrochloride racemic mixture

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

(±)-Sertraline hydrochloride, 1R,4R)-rel-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride

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Fórmula empírica (notación de Hill):
C17H17Cl2N · HCl
Número CAS:
79617-89-3
Peso molecular:
342.69
NACRES:
NA.24
PubChem Substance ID:
329751091
UNSPSC Code:
41116107
MDL number:
MFCD00895772

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InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

SMILES string

Cl.CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

grade

pharmaceutical primary standard

API family

sertraline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... SLC6A4(6532)

Categorías relacionadas

General description

Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.

Application

Sertraline hydrochloride racemic mixture USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Sertraline Hydrochloride Tablets
  • Sertraline Hydrochloride

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Aquatic ecotoxicity of the selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of freshwater test species.
Minagh E
Ecotox. Environ. Safety, 72(2), 434-440 (2009)
Effect of sertraline hydrochloride on dialysis hypotension.
Dheenan S
American Journal of Kidney Diseases, 31(4), 624-630 (1998)
Nachshon Korem et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(12), 2709-2722 (2014-06-06)
Posttraumatic stress disorder (PTSD) can develop following exposure to a traumatic event. Hence, what we do in the first few hours after trauma exposure may alter the trajectory of PTSD. We examined whether cannabinoids can prevent the effects of a
Eman G Nouman et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 37-45 (2015-03-24)
Dabigatran etexilate (DABE) is a low-molecular-weight prodrug that is converted after oral administration to dabigatran (DAB)-a directly acting oral anticoagulant. In this study, an LC-MSMS assay was developed and validated for the determination of DABE, free DAB and its equipotent
Baolian Wang et al.
Journal of ethnopharmacology, 155(3), 1473-1482 (2014-08-06)
Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) and more recently in western medicine for its antihepatotoxic effect. To

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