739979
Resomer® RG 858 S, Poly(D,L-lactide-co-glycolide)
ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000
Synonym(s):
PLGA
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About This Item
Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
Quality Level
form
amorphous
feed ratio
lactide:glycolide 85:15
mol wt
Mw 190,000-240,000
degradation timeframe
<9 months
viscosity
1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
storage temp.
2-8°C
SMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
General description
RESOMER® polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization. These biodegradeable homopolymers and copolymers of lactide and glycolide afford a variety of properties that range from very stiff, hard semi-crystalline materials with long degradation times, to softer, amorphous materials with faster degradation rates.
Application
Controlled release
Electrospun Resomer® X 206 S blended with cellulose from bagasse can be used as a scaffold in tissue engineering.
Features and Benefits
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
非細胞性バイオプリンティングと細胞性バイオプリンティングの2種類の方法について、構造体に適した材料や製作方法を簡単に紹介します。
生分解性脂肪族ポリエステルはDDS分野での抗がん剤送達用途で注目されており、ポリエステルの合成、刺激応答性薬物担体、能動的標的化を中心に詳細をご紹介します。
ポリラクチドおよびポリグリコリドを含む脂肪族ポリエステルは、医療用途に広く使用されている生分解性ポリマーです。
RESOMER??Biodegradeable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Mader K
Material Matters, 6(3), 62-62 (2011)
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or