인라인 및 실시간 라만 모니터링

관련 리소스

• Article: Direct Upstream Monitoring with Raman Ready-to-Use Models

  Learn how Raman ready-to-use models simplify calibration and allow real-time monitoring of CPPs and CQAs in upstream processes - no custom calibration required. See results from upstream and downstream runs and how transfer learning can fine-tune model accuracy after a single batch.

• Application Note: In-Line Monitoring of CPPs and Capsid Titer in Upstream AAV Process with ProCellics™ Raman Analyzer

  Explore the ProCellics™ Raman Analyzer for in-line monitoring of critical process parameters (CPPs) and capsid titer during AAV production in Human Embryonic Kidney (HEK) cell bioreactors.

• Data Sheet: ProCellics™ Raman Analyzer with Bio4C^® PAT Raman Software

  Specifically designed for the bioprocessing industry, ProCellics™ Raman Analyzer with Bio4C^® PAT Raman Software enables you to perform in-line and real-time measurement of CPPs and CQAs, from process development to manufacturing.

• Application Note: Enabling accelerated Raman model calibration for seamless and reproducible real-time monitoring by combining Raman and automated sampling technologies

  Explore how automated sampling can accelerate the integration of a Raman analyzer for a bioreactor application, speeding up the Raman model building phase, and facilitating in-line, real-time monitoring of critical process parameters (CPPs) and critical quality attributes (CQAs) during the manufacturing process.

• Application Note: Monitoring bioprocesses in a light environment using Raman spectroscopy

  This application note introduces an advanced solution to facilitate the implementation of Raman technology in laboratory and manufacturing scales, in a normal light environment, to ensure the consistent monitoring of critical process parameters (CPPs) and critical quality attributes (CQAs).

• Application Note: An innovative approach to streamline Raman implementation for cell culture processes: One-batch calibration

  This novel modeling approach eliminates the need for multiple calibration batches during the Raman implementation, allowing for a more streamlined and efficient workflow.

• Application Note: Real-time and in-line Raman Spectroscopy: A Window into Glycosylation Quality Analysis

  This case study demonstrates the effectiveness of Raman technology for monitoring monoclonal antibody (mAb) glycan profiles during fed-batch processes, and how robust predictive models facilitate monitoring of glycosylation profiles.

• Application Note: In-line Real-time Monitoring of CHO Cell Culture Process Parameters Using Raman Spectroscopy

  Cell culture processes are complex and highly variable and yet only a handful of key parameters such as temperature, pH, and dissolved oxygen (DO) are typically controlled in real time.

• Application Note: Implementation of Raman Spectroscopy for In-line Monitoring of CPPs of CHO Cell Perfusion Cultures

  This application note introduces a case study for the implementation of a Raman spectroscopy soft-sensor for in-line and real-time monitoring of critical process parameters (CPP) in mammalian perfusion cell cultures.

• Application Note: Seamless Integration of Glucose Control Using Raman Spectroscopy in CHO Cell Cultures

  Process analytical technology (PAT) and quality by design (QbD) are used in the biopharmaceutical industry to ensure quality is designed into a process and to achieve innovative quality improvements.

• Application Note: Cell-free modelling approach for efficient cell culture monitoring using Raman spectroscopy

  The novel synthetic model approach provides a significative gain of time and resources for the Raman calibration phase which is reduced to just a few days.

• Article: One-Batch Calibration: A Process-, Instrument-, Scale- & Site-agnostic Method For Streamlining Raman Implementation

  Challenges associated with Raman spectroscopy implementation in bioprocesses can be overcome by the innovative one-batch calibration approach. This streamlined process requires less time and resources compared to traditional approaches, unlocking Raman benefits for biopharmaceutical applications.