160210
4-Nitrophenyl chloroformate
96%, for peptide synthesis
동의어(들):
Chloroformic acid 4-nitrophenyl ester
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
ClCO2C6H4NO2
CAS 번호:
Molecular Weight:
201.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352108
EC Number:
231-706-9
MDL number:
Beilstein/REAXYS Number:
518127
제품 이름
4-Nitrophenyl chloroformate, 96%
InChI key
NXLNNXIXOYSCMB-UHFFFAOYSA-N
InChI
1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H
SMILES string
[O-][N+](=O)c1ccc(OC(Cl)=O)cc1
assay
96%
form
powder
reaction suitability
reaction type: Carbonylations
bp
159-162 °C/19 mmHg (lit.)
mp
77-79 °C (lit.)
application(s)
peptide synthesis
storage temp.
2-8°C
Quality Level
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General description
4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.
Application
4-Nitrophenyl chloroformate is used as:
- A coupling agent to link the drug molecule with the polyrotaxane carrier molecule
- As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF)
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
저장 등급
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Zhuojun Gu et al.
Drug development and industrial pharmacy, 41(5), 812-818 (2014-04-22)
Polyamidoamine (PAMAM) dendrimers have attracted lots of interest as drug carriers. And little study about whether pluronic-attached PAMAM dendrimers could be potential drug delivery systems has been carried on. Pluronic F127 (PF127) attached PAMAM dendrimers were designed as novel drug
Macromolecular Rapid Communications, 15, 697-697 (1994)
Novel and Efficient Synthesis of 4-Substituted-1, 2, 4-triazolidine-3, 5-diones from Anilines.
Mallakpour S and Rafiee Z
Synthetic Communications, 37(11), 1927-1934 (2007)
4-Nitrophenyl chloroformate: A versatile coupling reagent.
Sammet B, et al.
Synlett, 2009(18), 3050-3051 (2009)
Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2, 4-quinazolindiones.
Choo Hea YP, et al.
Bioorganic & Medicinal Chemistry, 10(3), 517-523 (2002)
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