42085
1-Fluoro-2,4-dinitrobenzene
purum p.a., ≥98.0% (GC)
동의어(들):
2,4-Dinitro-1-fluorobenzene, DNFB, DNPF, FDNB, Sanger reagent
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(O2N)2C6H3F
CAS 번호:
Molecular Weight:
186.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-734-3
Beilstein/REAXYS Number:
398632
MDL number:
Assay:
≥98.0% (GC)
Form:
liquid
InChI key
LOTKRQAVGJMPNV-UHFFFAOYSA-N
InChI
1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
SMILES string
[O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O
grade
purum p.a.
assay
≥98.0% (GC)
form
liquid
Quality Level
bp
178 °C/25 mmHg (lit.)
density
1.482 g/mL at 25 °C (lit.)
cation traces
Ca: ≤50 mg/kg, Cd: ≤50 mg/kg, Co: ≤50 mg/kg, Cu: ≤50 mg/kg, Fe: ≤50 mg/kg, K: ≤100 mg/kg, Na: ≤100 mg/kg, Ni: ≤50 mg/kg, Pb: ≤50 mg/kg, Zn: ≤50 mg/kg
functional group
fluoro, nitro
storage temp.
2-8°C
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General description
1-Fluoro-2,4-dinitrobenzene(FDNB, Sanger′s reagent) is used to identify the amino acid sequence. Thischemical is used to label the free amino groups in proteins and peptides. Itcan also be used to protect the amine group, and for phenol deoxygenation. Additionally,it is a very helpful reagent for nucleophilic substitution reactions tointroduce a chromophore group to amines, phenols, and thiols.
Application
1-Fluoro-2,4-dinitrobenzene is used as a derivatization agent:
- For aminoglycoside compounds such as amikacine, tobramycine, gentamycine, sisomycine, neamine, neomycine-B and neomycine-C.
- To examine the kinetic analysis and analytical uses of reaction with thiols in the presence of several surfactants.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
327.2 °F
flash_point_c
164 °C
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Spectrophotometric determination of lisinopril in tablets using 1-fluoro-2,4-dinitrobenzene reagent.
G Paraskevas et al.
Journal of pharmaceutical and biomedical analysis, 29(5), 865-872 (2002-07-03)
A spectrophotometric method for the determination of lisinopril (LN) in single and multicomponent tablets also containing hydrochlorothiazide (HCT), based on the derivatization reaction with 1-fluoro-2,4-dinitrobenzene (FDNB, Sanger reagent) is described. Aqueous solutions of LN (4.5-27.2 x 10(-5) M) react with
F Wang et al.
Journal of chromatography. A, 883(1-2), 113-118 (2000-07-26)
A rapid and simple method is presented for determining neuro-excitatory nonprotein amino acid 3-N-oxalyl-2,3-diaminopropionic acid (beta-ODAP) and non-protein amino acids in Lathyrus sativus. Seed and foliage extracts of Lathyrus sativus were treated with 1-fluoro-2,4-dinitrobenzene (FDNB) and a reversed-phase high-performance liquid
Morten M Nielsen et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 2975-2983 (2014-03-07)
Substances that penetrate the skin surface can act as allergens and induce a T cell-mediated inflammatory skin disease called contact hypersensitivity (CHS). IL-17 is a key cytokine in CHS and was originally thought to be produced solely by CD4(+) T
Sonia Schuepbach-Mallepell et al.
The Journal of allergy and clinical immunology, 132(6), 1348-1357 (2013-08-21)
Innate immune sensors control key cytokines that regulate T-cell priming and T-cell fate. This is particularly evident in allergic reactions, which represent ideal systems to study the interplay of innate and adaptive immunity. In patients with contact dermatitis, inflammasome-mediated IL-1
Helena Shifrin et al.
PloS one, 8(2), e57668-e57668 (2013-03-08)
The cholinergic anti-inflammatory system and α7 nicotinic receptors in macrophages have been proposed to play a role in neuroimmunomodulation and in the etiology of ulcerative colitis. We investigated the ability of a cholinesterase (ChE) inhibitor rivastigmine, to improve the pathology
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