P21005
4-Phenylbutyric acid
99%
동의어(들):
γ-Phenylbutanoic acid, ψ-Phenylbutanoic acid, 4-Phenyl-n-butyric acid, 4-Phenylbutanoic acid, Benzenebutyric acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C6H5(CH2)3COOH
CAS 번호:
Molecular Weight:
164.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-341-8
Beilstein/REAXYS Number:
638180
MDL number:
Assay:
99%
Form:
crystals
InChI
1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)
InChI key
OBKXEAXTFZPCHS-UHFFFAOYSA-N
SMILES string
OC(=O)CCCc1ccccc1
assay
99%
form
crystals
bp
165 °C/10 mmHg (lit.)
Quality Level
mp
49-51 °C (lit.)
General description
4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders.
Application
4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).
It can also be used as a reactant in the synthesis of:
It can also be used as a reactant in the synthesis of:
- 1-Tetralone using Lewis acid catalyst.
- 4,N-diphenylbutyramide.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
Kolb PS, et al.
The International Journal of Biochemistry & Cell Biology, 61, 45-52 (2015)
Synthesis of 1-tetralones by intramolecular Friedel?Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts
Cui DM, et al.
Tetrahedron Letters, 44(21), 4007-4010 (2003)
Clean, reusable and low cost heterogeneous catalyst for amide synthesis
Comerford JW, et al.
Chemical Communications (Cambridge, England), 18(21), 2562-2564 (2009)
Induction of apoptosis coupled to endoplasmic reticulum stress through regulation of CHOP and JNK in bone marrow mesenchymal stem cells from patients with systemic lupus erythematosus
Guo G, et al.
Journal of immunology research (2015)
Min Han Kim et al.
Clinical and experimental otorhinolaryngology, 12(2), 181-189 (2018-10-20)
Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and activating transcription factor 6 (ATF6) play important roles in ER stress-related
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