제품 이름
17:0-20:4 PI(5)P, Avanti Research™ - A Croda Brand LM1902, powder
form
powder
manufacturer/tradename
Avanti Research™ - A Croda Brand LM1902
packaging
1 ea of 1 × (with stopper and crimp cap (LM1902-1EA))
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]
InChI
1S/C46H82O16P2.2H3N/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)60-38(36-58-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-59-64(56,57)62-46-43(51)41(49)42(50)45(44(46)52)61-63(53,54)55;;/h11,13,17,19,21,23,27,29,38,41-46,49-52H,3-10,
InChI key
IOJKXWHTFCVKEI-QBMVDDEMSA-N
General description
Phosphatidylinositol 5-Phosphate (PI5P) is present in the endosomes, trans-Golgi network and smooth endoplasmic reticulum. It is abundantly localized to the plasma membrane but also found in the intracellular membranes of the organelles.
Biochem/physiol Actions
Phosphorylation of phosphatidylinositol 5-phosphate (PI5P) by phosphatidylinositol 5-phosphate (PI5P) type II PIPKs (PIPKIIs) produces phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2), which, is a potent signaling molecule. PI5P is a lipid messenger associated with stress-induced pathways in the nucleus. It is known to possess housekeeping functions and aids in cell activation during bacterial infections.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (LM1902-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
Amber J McCartney et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 36(1), 52-64 (2013-12-11)
Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2 ), reveal an intriguingly diverse list of downstream pathways, the intertwined relationship between PI(3,5)P2 and PI5P, as well as links to neurodegenerative diseases. Derived from the structural lipid phosphatidylinositol
Natsuko Jin et al.
Biochemical Society transactions, 44(1), 177-184 (2016-02-11)
Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. The low-abundance signalling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is critical for cellular homoeostasis and adaptation to stimuli. A large complex of proteins that includes the lipid kinase Fab1-PIKfyve
Matthew W Bunce et al.
The Journal of biological chemistry, 283(13), 8678-8686 (2008-01-26)
Phosphoinositide signaling pathways regulate numerous processes in eukaryotic cells, including migration, proliferation, and survival. The regulatory lipid phosphatidylinositol 4,5-bisphosphate is synthesized by two distinct classes of phosphatidylinositol phosphate kinases (PIPKs), the type I and II PIPKs. Although numerous physiological functions