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217708

ML141

≥99% (HPLC), solid, Cdc42/Rac1 GTPase inhibitor, Calbiochem®

동의어(들):

Cdc42/Rac1 GTPase Inhibitor, ML141, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II, CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyra, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II, CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyraz

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C22H21N3O3S
CAS 번호:
71203-35-5
Molecular Weight:
407.49
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
MFCD05987165
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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제품 이름

Cdc42/Rac1 GTPase Inhibitor, ML141, The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications.

Quality Level

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)

InChI key

QBNZBMVRFYREHK-UHFFFAOYSA-N

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관련 카테고리

General description

A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 >100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (>95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. . 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hong, L., et al. 2012. J. Biol. Chem.in press.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Golnaz Morad et al.
International journal of molecular sciences, 21(11) (2020-06-03)
Breast cancer brain metastasis is a major clinical challenge and is associated with a dismal prognosis. Understanding the mechanisms underlying the early stages of brain metastasis can provide opportunities to develop efficient diagnostics and therapeutics for this significant clinical challenge.

국제 무역 품목 번호

SKUGTIN
217708-25MGCN04055977202366

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