description
Merck USA index - 14, 4990
assay
≥95% (SDS-PAGE)
form
liquid
specific activity
≥3.5 x 104 units/mL
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−70°C
Quality Level
General description
Recombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer.
Other Notes
Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer61, 110.
Dianzani, F. 1993. Gut34, 574.
Brouty-Boyce, D., and Zetter, B.R. 1990. Science208, 516.
Sidky, Y.A., and Borden, E.C. 1987. Cancer Res.47, 5155.
Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol.119, 34.
Pestka, S. 1986. Methods Enzymol.119, 14.
Familletti, P.C., et al. 1981. Methods Enzymol.78, 387.
Johnson, M.D., et al. 1981. Methods Enzymol.78, 394.
Rubinstein, S., et al. 1981. J. Virol.37, 755.
Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer61, 110.
Dianzani, F. 1993. Gut34, 574.
Brouty-Boyce, D., and Zetter, B.R. 1990. Science208, 516.
Sidky, Y.A., and Borden, E.C. 1987. Cancer Res.47, 5155.
Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol.119, 34.
Pestka, S. 1986. Methods Enzymol.119, 14.
Familletti, P.C., et al. 1981. Methods Enzymol.78, 387.
Johnson, M.D., et al. 1981. Methods Enzymol.78, 394.
Rubinstein, S., et al. 1981. J. Virol.37, 755.
One unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
W Markland et al.
Antimicrobial agents and chemotherapy, 44(4), 859-866 (2000-03-18)
The enzyme IMP dehydrogenase (IMPDH) catalyzes an essential step in the de novo biosynthesis of guanine nucleotides, namely, the conversion of IMP to XMP. The major event occurring in cells exposed to competitive IMPDH inhibitors such as ribavirin or uncompetitive
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 407293-100KUCN | 04055977188196 |
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