557370
Rottlerin
≥98% (HPLC), solid, PKC inhibitor, Calbiochem®
동의어(들):
Rottlerin, Mallotoxin
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C30H28O8
CAS 번호:
Molecular Weight:
516.54
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
제품 이름
Rottlerin, A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ.
Quality Level
description
Merck USA index - 14, 8272
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
orange
solubility
ethanol: 1 mg/mL, DMSO: 30 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
O1C(C=Cc2c1c(c(c(c2O)Cc4c(c(c(c(c4O)C(=O)C)O)C)O)O)C(=O)\C=C\c3ccccc3)(C)C
InChI
1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
InChI key
DEZFNHCVIZBHBI-ZHACJKMWSA-N
General description
A cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCΘ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKCδ
PKCδ
Product does not compete with ATP.
Reversible: yes
Target IC50: 3-6 µM against PKCδ; 5.3 µM against CaM kinase III
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Villalba, M., et al. 1999. J. Immunol. 163, 5813.
Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
Gschwendt, M., et al. 1994. FEBS Lett.338, 85.
Gschwendt, M., et al. 1984. Cancer Lett.25, 177.
Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
Gschwendt, M., et al. 1994. FEBS Lett.338, 85.
Gschwendt, M., et al. 1984. Cancer Lett.25, 177.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 분석 증명서(COA)를 검색하십시오. 로트 및 배치 번호는 제품 라벨의 ‘Lot’ 또는 ‘Batch’라는 단어 뒤에 기재되어 있습니다.