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Merck

MABN328

Sigma-Aldrich

Anti-peptidyl-citrulline, clone F95 Antibody

clone F95, from mouse

동의어(들):

Peptidyl-citrulline, Protein-bound citrulline

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크기 선택


제품정보 (DICE 배송 시 비용 별도)

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
기술 서비스
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기술 서비스
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생물학적 소스

mouse

Quality Level

항체 형태

purified antibody

항체 생산 유형

primary antibodies

클론

F95, monoclonal

종 반응성

mouse, rat, chicken, human

종 반응성(상동성에 의해 예측)

all (based on 100% sequence homology)

기술

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

동형

IgMκ

배송 상태

wet ice

타겟 번역 후 변형

unmodified

일반 설명

Deimination (citrullination) is a post translational modification in which the peptidyl-arginine deiminase family of enzymes convert the guanidino side chain of the amino acid arginine into a ureido group, yeilding peptidyl-citrulline. As a result, anti-peptidyl-citrulline antibodies should also cross react with peptidyl-homocitrulline, produced by the carbamylation of lysine, but not free citrulline, which is created in the urea cycle, or as a by-product of nitric oxide synthesis.
Various kDa calculated

면역원

Citrullinated peptide consisting of 10 citrulline residues and a carboxyl Gly-Gly-Cys.

애플리케이션

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected peptidyl-citrulline in human cerebellum, and rat cerebellum tissue.
Western Blotting Analysis: A representative lot detected peptidyl-citrulline in CNS proteins from brains and spinal cord of EAE mice (Nicholas et al., 2005).
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
This Anti-peptidyl-citrulline, clone F95 Antibody is validated for use in Immunohistochemistry and Western Blotting and Immunocytochemistry for the detection of peptidyl-citrulline.

물리적 형태

Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

제조 메모

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Evaluated by Immunohistochemistry in human cerebral cortex tissue.

Imunnohistochemistry Analysis: A 1:250 dilution of this antibody detected peptidyl-citrulline inhuman cerebral cortex tissue.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문


Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra.
Nicholas, Anthony P
Neuroscience Letters, 495, 26-29 (2011)
Leen De Rycke et al.
Arthritis and rheumatism, 52(8), 2323-2330 (2005-07-30)
To address the ongoing debate concerning the specificity of synovial citrullinated proteins for rheumatoid arthritis (RA) and to analyze their pathophysiologic relevance to the induction or perpetuation of the RA-specific anti-citrullinated protein antibodies (ACPAs). Synovium of 19 RA patients and
Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitis.
Nicholas, Anthony P, et al.
The Journal of Comparative Neurology, 486, 254-266 (2005)



국제 무역 품목 번호

SKUGTIN
MABN32804053252996184