SMILES string
N21[C@]([C@H]4N[C@H]4C2)([C@@H](C3=C1C(=O)C(=C(C3=O)N)C)COC(=O)N)OC
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
assay
98%
form
crystalline powder
mol wt
334.3
packaging
pkg of 2 mg
manufacturer/tradename
Roche
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
General description
Mitomycin C is an antitumor antibiotic.
Application
Mitomycin C has been used:
- to cease mitosis
- in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
- as mutagen in mutagenicity assay
Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.
Biochem/physiol Actions
Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.
Other Notes
For life science research only. Not for use in diagnostic procedures.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
Natalia Garcia-Becerra et al.
Cancers, 15(2) (2023-01-22)
Cervical cancer (CC) is the fourth most common type of cancer among women; the main predisposing factor is persistent infection by high-risk human papillomavirus (hr-HPV), mainly the 16 or 18 genotypes. Both hr-HPVs are known to manipulate the cellular machinery
Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system
Segunda MN, et al.
Theriogenology, 130, 8-18 (2019)
Microbial Mutagenicity Assay: Ames Test
Vijay U, et al.
Bio-protocol, e3854-e3854 (2018)
Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells
Jozefczuk J, et al.
Journal of Visualized Experiments, 130(64), e3854-e3854 (2012)
Mitomycin C: mechanism of action, usefulness and limitations
Verweij J and Pinedo HM
Anti-Cancer Drugs, 1(1), 5-13 (1990)
문서
Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic
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