General description
Transferrin is a serum glycoprotein that participates in the transport of iron from absorption and storage sites to tissue cells. The iron-bound transferrin, also referred to as ferrotransferrin, binds to specific cell surface receptors on growing cells and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.
Application
Transferrin, similar to insulin, is a component of most serum-free media formulations. The main function of transferrin is to transport iron into cells by receptor-mediated endocytosis.
Transferrin from human serum has been used as a supplement in:
Transferrin from human serum has been used as a supplement in:
- differentiation medium
- keratinocyte medium
- haemogenic endothelium culture medium
- embryoid-body medium
- blast colony forming cell-culture medium
Physical form
Solution, 30 mg/ml in IMDM, filtered through 0.2 μm pore size membrane. Iron saturation is below 1%. This product is Apo-Transferrin.
Preparation Note
Working concentration: 1 to 100 μg/ml
Store at 2 to 8 °C. (lyophilizate and solution)
Other Notes
For life science research only. Not for use in diagnostic procedures.
wgk
WGK 1
flash_point_f
No data available
flash_point_c
No data available
Zhiru Guo et al.
Journal of visualized experiments : JoVE, (49)(49), doi:10-doi:10 (2011-04-15)
The homeostasis of all self-renewing tissues is dependent on adult stem cells. As undifferentiated stem cells undergo asymmetric divisions, they generate daughter cells that retain the stem cell phenotype and transit-amplifying cells (TA cells) that migrate from the stem cell
Quantification of Mouse Hematopoietic Progenitors? Formation Using Time-lapse Microscopy and Image Analysis
Bergiers I, et al.
Bio-protocol, 9(1), e3137-e3137 (2019)
Iron deficiency affects early stages of embryonic hematopoiesis but not the
endothelial to hematopoietic transition.
endothelial to hematopoietic transition.
Shvartsman M, et al.
bioRxiv (2018)
Özge Vargel et al.
Scientific reports, 6, 21518-21518 (2016-02-20)
The endothelial to haematopoietic transition (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to the formation of blood stem and progenitor cells during embryogenesis. As TGFβ signalling triggers a similar event during embryonic
T J M Welting et al.
European cells & materials, 22, 420-436 (2011-12-21)
Skeletogenesis and bone fracture healing involve endochondral ossification, a process during which cartilaginous primordia are gradually replaced by bone tissue. In line with a role for cyclooxygenase-2 (COX-2) in the endochondral ossification process, non-steroidal anti-inflammatory drugs (NSAIDs) were reported to
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