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Merck

11709

Barbituric acid

for spectrophotometric det. of cyanide, ≥99.5%

동의어(들):

2,4,6-Trihydroxypyrimidine, Malonylurea

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C4H4N2O3
CAS 번호:
Molecular Weight:
128.09
UNSPSC Code:
41115710
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-658-0
Beilstein/REAXYS Number:
120502
MDL number:
Assay:
≥99.5% (HPLC), ≥99.5%
Form:
solid
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InChI key

HNYOPLTXPVRDBG-UHFFFAOYSA-N

InChI

1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)

SMILES string

O=C1CC(=O)NC(=O)N1

assay

≥99.5% (HPLC), ≥99.5%

form

solid

quality

for spectrophotometric det. of cyanide

technique(s)

UV/Vis spectroscopy: suitable

ign. residue

≤0.05%

mp

248-252 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤500 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, Mg: ≤10 mg/kg, Mn: ≤5 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

Quality Level

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General description

Barbituric acid is also known as malonurea or 6-hydroxyuracil, it is an odourless powder and is soluble in water. It has a very high pharmacological activity and can be used to synthesize addition derivatives of it, to be used in novel drug discovery. It basically acts on the central nervous system (CNS) depressants, thereby possessing a wide range from mild sedation to total anaesthesia.

Application

Barbituric acid with aromatic aldehydes was used in an experimental study, meant to demonstrate the increased efficiency of Knoevenagel condensation reaction for barbituric acid and various aromatic aldehydes on basic alumina, in the absence of organic solvents under microwave irradiation. It may also be used in electrochemical oxidation of iodine, using cyclic voltammetry and controlled-potential coulometry.

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

302.0 °F - closed cup

flash_point_c

150.00 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Electrochemical study of iodide in the presence of barbituric acid. Application to coulometric titration of barbituric acid.
Nematollahi D and Hesari M
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 70 (1), 7-11 (2001)
Microwave enhanced knoevenagel condensation of barbituric acid with aromatic aldehydes on basic alumina.
Khalafi NA and Hashemi A.
Iranian Journal of Chemistry and Chemical Engineering, 20 (1), 9-11 (2001)
Bioactive Heterocyclic Compound Classes.
Clemens L and Dinges J.
Pharmaceutics, 24-27 (2012)
Sergio Hidalgo-Figueroa et al.
Chemical biology & drug design, 81(4), 474-483 (2013-01-08)
A small series of thiazolidine-2,4-dione and barbituric acid derivatives 1-4 was prepared using a short synthetic route, and all compounds were characterized by elemental analysis, mass spectrometry, and NMR ((1)H, (13)C) spectroscopy. Their in vitro relative expression of peroxisome proliferator-activated
David C Chiara et al.
The Journal of biological chemistry, 288(27), 19343-19357 (2013-05-17)
GABA type A receptors (GABAAR), the brain's major inhibitory neurotransmitter receptors, are the targets for many general anesthetics, including volatile anesthetics, etomidate, propofol, and barbiturates. How such structurally diverse agents can act similarly as positive allosteric modulators of GABAARs remains

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