65943
N-Methyl-bis(trifluoroacetamide)
derivatization grade (GC derivatization), LiChropur™, ≥99.0% (GC)
동의어(들):
MBTFA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CF3CON(CH3)COCF3
CAS 번호:
Molecular Weight:
223.07
UNSPSC Code:
23151817
NACRES:
NA.22
PubChem Substance ID:
EC Number:
211-680-5
Beilstein/REAXYS Number:
1878402
MDL number:
Assay:
≥99.0% (GC)
grade
derivatization grade (GC derivatization)
Quality Level
assay
≥99.0% (GC)
quality
LiChropur™
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations, reagent type: derivatization reagent
reaction type: Silylations
technique(s)
gas chromatography (GC): suitable
refractive index
n20/D 1.346
bp
121-122 °C (lit.)
density
1.547 g/mL at 25 °C
SMILES string
CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F
InChI
1S/C5H3F6NO2/c1-12(2(13)4(6,7)8)3(14)5(9,10)11/h1H3
InChI key
AWGBWLXGUPTXHF-UHFFFAOYSA-N
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General description
N-Methyl-bis(trifluoroacetamide) is a common reagent used in the alkylation process, which targets highly polar, multi-functional compounds such as carbohydrates and amino acids.
Application
Reagent for introducing trifluoroacetyl group.
N-Methyl-bis(trifluoroacetamide) may be used as an on-column derivatization agent for the determination of amphetamine-type stimulants in biological samples, and ketamine, norketamine, dehydronorketamine in urine samples using gas chromatography coupled to mass spectrometry technique.
It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions.
Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B6 vitamers), and thiols.
It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions.
Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B6 vitamers), and thiols.
Other Notes
Reagent for trifluoroacetyl, N-trimethylsilyl-N-tifluoroacetyl and trimethylsilyl.
Reagent for trifluoroacetylations under mild conditions
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Flam. Liq. 3 - Skin Corr. 1B
저장 등급
3 - Flammable liquids
wgk
WGK 3
flash_point_f
113.0 °F - closed cup
flash_point_c
45 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Development of a two-step injector for GC?MS with on-column derivatization, and its application to the determination of amphetamine-type stimulants (ATS) in biological specimens
Miki A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 865(1-2), 25-32 (2008)
K. Blau et al.
Handbook of Derivatives for Chromatography, 131-131 (1977)
[Acylation with bis(acylamides). N-methyl-bis(trifluoroacetamide) and bis(trifluoroacetamide), two new reagents for trifluoroacetylation].
M Donike
Journal of chromatography, 78(2), 273-279 (1973-04-25)
H Tsuchihashi et al.
Journal of chromatography, 467(1), 227-235 (1989-04-21)
The analysis of stimulants in urine using a headspace gas chromatography system equipped with an in-column sample trifluoroacetylation unit was investigated. A 5-ml aliquot of urine containing stimulants was pipetted into a 20-ml autosampler vial together with 3.5 g of
N Pizarro et al.
Journal of pharmaceutical and biomedical analysis, 21(4), 739-747 (2000-03-04)
We developed a fast and sensitive method for identification and quantification of plasma concentrations of amphetamine using gas chromatography with mass spectrometry detection (GC-MS). Amphetamine-d8 served as internal standard. The method involves a single extraction procedure and an easy treatment
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