E3768
(−)-Epigallocatechin
≥95% (HPLC), from green tea
동의어(들):
(−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol, (−)-cis-3,3′,4′,5,5′,7-Hexahydroxyflavane
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H14O7
CAS 번호:
Molecular Weight:
306.27
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
biological source
green tea
Quality Level
assay
≥95% (HPLC)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3
InChI
1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
InChI key
XMOCLSLCDHWDHP-IUODEOHRSA-N
Gene Information
human ... CYP1A2(1544)
General description
(−)-Epigallocatechin is one of the main catechin compounds found in green tea and the most abundant one (~20%), with antioxidant properties.
Application
(−)-Epigallocatechin (EGC) has been used:
- as a reference standard in high-performance liquid chromatography (HPLC) analysis
- to analyze its inhibitory effect on α-amylase and α-glucosidase activity to control postprandial hyperglycemia in Diabetes mellitus
- in cell viability assays to check its efficacy and protection against ferroptosis and iron toxicity in murine pancreatic β-cells
- to evaluate its potential anti-inflammatory effects on long-term acute and chronic Pristen-induced arthritis
- to treat pregnant and nursing mice, on in vitro angiogenesis, proliferation, and movement of endothelial cells
- to evaluate its effect on pregnant and nursing mice spleen based on the number and localization of CD4+ (cluster of differentiation 4) and CD8+ cluster of differentiation 8) cells
Biochem/physiol Actions
(−)-Epigallocatechin (EGC) has proven to be an anti-cancer agent by its inhibitory effects on heregulin-b1 (HRG)-induced migration/invasion in MCF-7 human breast carcinoma cells. It has also shown strong antiviral activity against the herpes simplex virus.
Green tea polyphenol. Anticancer agent. Lower antioxidant activity than EGCG.
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저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
문서
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.