I1762
Isoxicam
analytical standard
동의어(들):
4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C14H13N3O5S
CAS 번호:
Molecular Weight:
335.34
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-084-5
MDL number:
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
CN1C(C(=O)Nc2cc(C)on2)=C(O)c3ccccc3S1(=O)=O
InChI
1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)
InChI key
YYUAYBYLJSNDCX-UHFFFAOYSA-N
Gene Information
human ... PTGS1(5742), PTGS2(5743)
General description
Isoxicam is a long acting anti-inflammatory agent belonging to the oxicam group, and helps in relieving the symptoms of degenerative joint disease and rheumatoid arthritis. Its mode of action involves the ability to inhibit prostaglandin synthesis by suppressing the formation of cyclooxygenase and subsequent prostaglandin.
Application
Isoxicam may be used as an internal standard for the quantification of meloxicam in pharmaceutical preparations and as an analytical reference standard for the quantification of the analyte in biological samples using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N Bellamy et al.
The Journal of rheumatology, 15(12), 1833-1840 (1988-12-01)
Within the context of a double blind randomized controlled parallel trial of 2 nonsteroidal antiinflammatory drugs, we validated WOMAC, a new multidimensional, self-administered health status instrument for patients with osteoarthritis of the hip or knee. The pain, stiffness and physical
T F Woolf et al.
Drug metabolism and disposition: the biological fate of chemicals, 17(6), 662-668 (1989-11-01)
Isoxicam is a long half-life nonsteroidal anti-inflammatory agent which undergoes extensive metabolism prior to elimination in animals and man. The major route of isoxicam transformation is hydroxylation of the methylisoxazole functionality to form hydroxymethylisoxicam, and cleavage of its benzothiazine moiety
G Caillé et al.
Biopharmaceutics & drug disposition, 8(1), 57-61 (1987-01-01)
This study was designed to determine whether the disposition of isoxicam is influenced by the coadministration of another acidic drug, highly bound to plasma proteins and extensively metabolized, i.e., phenytoin. Ten healthy volunteers received an oral dose of 200 mg
W Frankhof
Current medical research and opinion, 11(1), 28-33 (1988-01-01)
The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications were administered once daily for 4 weeks in a controlled, randomized, double-blind
A review of HPLC methods used for determining the presence of meloxicam
Brezovska M, et al.
Current Pharmaceutical Analysis, 9(1), 69-76 (2013)
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