P1061
Proadifen hydrochloride
analytical standard, ≥95%
동의어(들):
α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester, N,N-Diethylaminoethyl 2,2-diphenylvalerate, SKF-525A
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C23H31NO2 · HCl
CAS 번호:
Molecular Weight:
389.96
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
SMILES string
Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2
InChI key
FHIKZROVIDCMJA-UHFFFAOYSA-N
grade
analytical standard
assay
≥95%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
122-123 °C
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
Application
Proadifen hydrochloride may be used as an internal standard in the determination of analgesic agents like O-desmethyltramadol, tramadol and N-desmethyltramadol in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase and cytochrome P450
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography?mass spectrometry
El-Sayed Y A-A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 926, 9-15 (2013)
Michael R Franklin et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2539-2546 (2008-09-19)
When incubated with human liver microsomes, 2-diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) undergoes cytochrome P450 (P450)-dependent oxidative N-deethylation to the secondary amine metabolite 2-ethylaminoethyl-2,2-diphenylvalerate (SKF8742). P450-selective inhibitors indicated CYP3As catalyzed this reaction, and the deethylation rate correlated best with the CYP3A activity across a
Xian Wu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 157(2), 410-420 (2017-04-04)
Human neural progenitor cells are capable of independent, directed differentiation into astrocytes, oligodendrocytes and neurons and thus offer a potential cell source for developmental neurotoxicity (DNT) systems. Human neural progenitor-derived astrocyte-neuron cocultured at defined ratios mimic cellular heterogeneity and interaction
David Fuchs et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(4), 158611-158611 (2020-01-10)
Trihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived lipid mediators reported to be dysregulated in obstructive lung disease. In contrast to many other oxylipins, TriHOME biosynthesis in humans is still poorly understood. The association of TriHOMEs with inflammation prompted the current investigation
María Eugenia Letelier et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(7), 1310-1313 (2011-05-17)
Adverse reactions of acetaminophen have been associated to oxidative stress, which may be elicited by reactive oxygen species (ROS) and/or production of the metabolite NAPQI. Both phenomena would arise through the activity of liver cytochrome P450 (CYP450) system, but their
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