P5654
Piroxicam
≥98% (TLC)
동의어(들):
4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H13N3O4S
CAS 번호:
Molecular Weight:
331.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-974-3
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
storage temp.
2-8°C
SMILES string
CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O
InChI
1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
InChI key
QYSPLQLAKJAUJT-UHFFFAOYSA-N
Gene Information
human ... PTGS1(5742), PTGS2(5743)
rat ... Alox5(25290)
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Application
Piroxicam has been used:
- for the induction of colitis in mice
- as a non-steroidal anti-inflammatory drug to increase the sensitivity to gut injury in interleukin-10 (IL-10) knockout mice
- as a chemopreventive agent and as a positive control to study its effects on tumor growth in mice small intestine
Biochem/physiol Actions
Cyclooxygenase inhibitor.
Piroxicam is a non‐steroidal anti‐inflammatory drug (NSAID). It possesses analgesic properties and exhibits therapeutic effects against rheumatic disorders.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT RE 2 Oral
target_organs
Gastrointestinal tract
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Lang M, et al.
Molecular Cancer, 12(1), 41-41 (2013)
Jiawei Guo et al.
Cell reports. Medicine, 4(1), 100881-100881 (2023-01-06)
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium and IL-10 knockout induced with piroxicam, bone mass and quality are significantly decreased.
Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study.
T J Carty et al.
Prostaglandins, 19(1), 51-59 (1980-01-01)
The new non-steroidal antiinflammatory (NSAI)2 agent, piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide], is a highly active inhibitor of prostaglandin (PG) synthesis by methylcholanthrene transformed mouse fibroblasts (MC5-5) and rabbit synovial cells in culture. Comparison of the PG biosynthesis inhibitory activity of piroxicam with
Seung-Won Choi et al.
Plant biotechnology (Tokyo, Japan), 39(3), 323-327 (2022-11-10)
Agrobacterium-mediated transformation is a key innovation for plant breeding, and routinely used in basic researches and applied biology. However, the transformation efficiency is often the limiting factor of this technique. In this study, we discovered that oxicam-type nonsteroidal anti-inflammatory drugs
Wanwadee Luksurapan et al.
Archives of physical medicine and rehabilitation, 94(2), 250-255 (2012-10-16)
To compare the effects of phonophoresis of piroxicam (PhP) and ultrasound therapy (UT) in patients with mild to moderate, symptomatic knee osteoarthritis (OA). A randomized, double-blind, controlled trial. Department of rehabilitation medicine, university hospital. Patients with knee OA (N=46; mean
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