P9672
Probucol
analytical standard
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C31H48O2S2
CAS 번호:
Molecular Weight:
516.84
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
245-560-9
MDL number:
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C
InChI
1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
InChI key
FYPMFJGVHOHGLL-UHFFFAOYSA-N
Gene Information
human ... ABCA1(19), IL1B(3553), IL6(3569), TNF(7124)
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General description
Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Enhances selective uptake of HDL-associated cholesteryl esters.
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Zhiwen Zhang et al.
International journal of pharmaceutics, 444(1-2), 162-168 (2013-01-24)
The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption
Atherosclerosis: Treatment and Prevention (2012)
Miwako Inagaki et al.
Journal of atherosclerosis and thrombosis, 19(7), 643-656 (2012-07-13)
High density lipoprotein (HDL) has multi-antiatherogenic effects such as antioxidation and anti-inflammation, in addition to being a key mediator of reverse cholesterol transport. Probucol, known as a lipid lowering drug, is also a potent antioxidant, but it decreases serum HDL
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics (2013)
Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
문서
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
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