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PHR1162

Loperamide hydrochloride

Name: Loperamide hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

LPM, 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride

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크기 선택

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₉H₃₃ClN₂O₂ · HCl

CAS 번호:

34552-83-5

Molecular Weight:

513.50

NACRES:

NA.24

PubChem Substance ID:

329823179

UNSPSC Code:

41116107

EC Number:

252-082-4

MDL number:

MFCD00058581

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도움 문의

속성

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. L0750000, traceable to USP 1370000

API family

loperamide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

Gene Information

human ... OPRM1(4988)

설명

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Loperamide hydrochloride finds application in the regulation and symptomatic relief of long acting diarrhea linked with inflammatory bowel diseases. It can also be used as a muscle relaxant agent.

Application

Loperamide hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3771 in the slot below. This is an example certificate only and may not be the lot that you receive.

Values of analytes vary lot to lot.

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 분석 증명서(COA)를 검색하십시오. 로트 및 배치 번호는 제품 라벨의 ‘Lot’ 또는 ‘Batch’라는 단어 뒤에 기재되어 있습니다.

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문서 라이브러리 방문

Spectrophotometric determination of loperamide hydrochloride by acid-dye and charge-transfer complexation methods in the presence of its degradation products

El Sherif ZA, et al.

Journal of Pharmaceutical and Biomedical Analysis, 22(1), 13-23 (2000)

Spectrofluorimetric and derivative absorption spectrophotometric techniques for the determination of loperamide hydrochloride in pharmaceutical formulations

Hewala II

Journal of Pharmaceutical and Biomedical Analysis, 13(6), 761-767 (1995)

Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride

Trottet L, et al.

International Journal of Pharmaceutics, 274(1-2), 213-219 (2004)

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