PHR1224
Aminocaproic acid
Pharmaceutical Secondary Standard; Certified Reference Material
동의어(들):
6-Aminocaproic acid, ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
H2N(CH2)5CO2H
CAS 번호:
Molecular Weight:
131.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-469-3
Beilstein/REAXYS Number:
906872
MDL number:
InChI key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES string
NCCCCCC(O)=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. A0420000, traceable to USP 1021000
API family
aminocaproic acid
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
207-209 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... PLAT(5327), PLG(5340)
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General description
Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Aminocaproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry and in bulk and injectable forms using colorimetric method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9036 in the slot below. This is an example certificate only and may not be the lot that you receive.
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
404.6 - 408.2 °F
flash_point_c
207 - 209 °C
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Development of Colorimetric Method for the Analysis of Aminocaproic Acid Using DCQ
Shantier SW, et al.
World Journal of Pharmaceutical Research, 4(4), 234-240 (2015)
Fluorimetric determination of aminocaproic acid in pharmaceutical formulations using a sequential injection analysis system
Pinto PCAG, et al.
Talanta, 68(3), 857-862 (2006)
The absorption, distribution, and excretion of ?-aminocaproic acid following oral or intravenous administration to man
McNicol GP, et al.
The Journal of Laboratory and Clinical Medicine, 59(1), 15-24 (1962)
Aminocaproic acid: use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia
Gardner FH and Helmer RE
JAMA : The Journal of the American Medical Association, 243(1), 35-37 (1980)
Ed M Choi et al.
Laboratory investigation; a journal of technical methods and pathology, 89(6), 624-635 (2009-05-13)
Recent cases of prion transmission in humans following transfusions using blood donated by patients with asymptomatic variant Creutzfeldt-Jakob disease (CJD) implicate the presence of prion infectivity in peripheral blood. In this study, we examined the levels of the normal, cellular
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